Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and
maintaining epithelial polarity. The claudin family of membrane proteins play central roles in …

Ceramides are sphingolipids and integral components of the eukaryotic cell membrane.
Apart from providing structural integrity, ceramides have also been shown to act as second …

Ceramides are bioactive sphingolipids that support the structure of the plasma membrane
and mediate numerous cell-signaling events in eukaryotic cells. The finding that ceramides …

Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …

The sphingolipid sphingosine‐1‐phosphate (S1P) emerges as an important regulator of
immunity, mainly by signaling through a family of five specific G protein‐coupled receptors …

To better understand the role of sphingolipids in the multifactorial process of inflammatory
bowel disease (IBD), we elucidated the role of CerS4 in colitis and colitis-associated cancer …

Drug resistance is one major reason for failure of cancer therapy. In the past 10 years,
evidence emerged showing that ceramides of specific chain length, generated by six …

Background There is an unmet medical need for biomarkers that capture host and
environmental contributions in inflammatory bowel diseases (IBDs). This study aimed at …

Abstract Background and Aims Heat shock protein 90 [Hsp90]-targeted therapy has been
proposed as a promising strategy for the treatment of ulcerative colitis [UC] and colitis …

Glycosphingolipids (GSLs) are a diverse group of membrane components occurring mainly
on the surfaces of mammalian cells. They and their metabolites have a role in intercellular …