Hirschsprung disease

L Montalva, LS Cheng, R Kapur, JC Langer… - Nature Reviews …, 2023 - nature.com
Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in
5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric …

Disorders of the enteric nervous system—a holistic view

B Niesler, S Kuerten, IE Demir… - … reviews Gastroenterology & …, 2021 - nature.com
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …

Hirschsprung disease—integrating basic science and clinical medicine to improve outcomes

RO Heuckeroth - Nature reviews Gastroenterology & hepatology, 2018 - nature.com
Hirschsprung disease is defined by the absence of enteric neurons at the end of the bowel.
The enteric nervous system (ENS) is the intrinsic nervous system of the bowel and regulates …

Enteric nervous system development: A crest cell's journey from neural tube to colon

N Nagy, AM Goldstein - Seminars in cell & developmental biology, 2017 - Elsevier
The enteric nervous system (ENS) is comprised of a network of neurons and glial cells that
are responsible for coordinating many aspects of gastrointestinal (GI) function. These cells …

New insights into the development of lymphoid tissues

SA Van de Pavert, RE Mebius - Nature Reviews Immunology, 2010 - nature.com
Secondary lymphoid organs are important locations for the initiation of adaptive immune
responses. They develop before birth, and their formation requires interaction between …

The developmental etiology and pathogenesis of Hirschsprung disease

NEB Tjaden, PA Trainor - Translational research, 2013 - Elsevier
The enteric nervous system is the part of the autonomic nervous system that directly controls
the gastrointestinal tract. Derived from a multipotent, migratory cell population called the …

Enteric nervous system development: migration, differentiation, and disease

JI Lake, RO Heuckeroth - American Journal of Physiology …, 2013 - journals.physiology.org
The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …

[HTML][HTML] The enteric nervous system

V Sasselli, V Pachnis, AJ Burns - Developmental biology, 2012 - Elsevier
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract,
consists of numerous types of neurons, and glial cells, that are distributed in two …

Building a brain in the gut: development of the enteric nervous system

AM Goldstein, RMW Hofstra, AJ Burns - Clinical genetics, 2013 - Wiley Online Library
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, is an
essential component of the gut neuromusculature and controls many aspects of gut function …

The science of Hirschsprung disease: what we know and where we are headed

JL Mueller, AM Goldstein - Seminars in pediatric surgery, 2022 - Elsevier
The enteric nervous system (ENS) is a rich network of neurons and glial cells that comprise
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …