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A critical evaluation of protein kinase regulation by activation loop autophosphorylation
R Reinhardt, TA Leonard - Elife, 2023 - elifesciences.org
Phosphorylation of proteins is a ubiquitous mechanism of regulating their function,
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …
LRRK2 in Parkinson's disease: upstream regulation and therapeutic targeting
Y **ong, J Yu - Trends in Molecular Medicine, 2024 - cell.com
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of
Parkinson's disease (PD) to date. Dysfunction in LRRK2 enzymatic activities and elevated …
Parkinson's disease (PD) to date. Dysfunction in LRRK2 enzymatic activities and elevated …
Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting …
Neurodegenerative diseases (NDs) are one of the prominent health challenges facing
contemporary society, and many efforts have been made to overcome and (or) control it. In …
contemporary society, and many efforts have been made to overcome and (or) control it. In …
Leucine‐rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule‐associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism
K Chen, F Tang, B Du, ZZ Yue, LL Jiao, XL Ding… - MedComm, 2023 - Wiley Online Library
Mutations in LRRK2 (encoding leucine‐rich repeat kinase 2 protein, LRRK2) are the most
common genetic risk factors for Parkinson's disease (PD), and increased LRRK2 kinase …
common genetic risk factors for Parkinson's disease (PD), and increased LRRK2 kinase …
Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase-dependent mechanism
BK Gilsbach, FY Ho, B Riebenbauer, X Zhang… - eLife, 2024 - elifesciences.org
The Parkinson's disease (PD)-linked protein Leucine-Rich Repeat Kinase 2 (LRRK2)
consists of seven domains, including a kinase and a Roc G domain. Despite the availability …
consists of seven domains, including a kinase and a Roc G domain. Despite the availability …
Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies
Roco proteins entered the limelight after mutations in human LRRK2 were identified as a
major cause of familial Parkinson's disease. LRRK2 is a large and complex protein …
major cause of familial Parkinson's disease. LRRK2 is a large and complex protein …
Leucine-rich repeat kinase 2 (LRRK2) inhibitors for Parkinson's disease: a patent review of the literature to date
M Morez, AJ Lara Ordóñez, P Melnyk… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Nearly two decades after leucine rich repeat kinase 2 (LRRK2) was discovered
as a genetic determinant of Parkinson's disease (PD), LRRK2 has emerged a priority …
as a genetic determinant of Parkinson's disease (PD), LRRK2 has emerged a priority …
Pathogenic genes associated with Parkinson's disease: molecular mechanism overview.
T Liu, Y Hao, L Zhao - Biocell, 2024 - search.ebscohost.com
Parkinson's disease (PD) is a common neurodegenerative disease in the elderly,
accounting for more than 1% of the population aged 65 years. Monogenic inheritance is …
accounting for more than 1% of the population aged 65 years. Monogenic inheritance is …
Full-length LRRK2 activation cycle and dimer-monomer equilibrium
X Zhang - 2024 - research.rug.nl
Mutations in the Leucine-rich repeat Kinase 2 (LRRK2) gene have been identified as
associated with Parkinson's disease (PD). Previous biochemical and cellular data indicated …
associated with Parkinson's disease (PD). Previous biochemical and cellular data indicated …