Drug discovery for cutaneous leishmaniasis: a review of developments in the past 15 years
Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …
Recent advancements in anti-leishmanial research: Synthetic strategies and structural activity relationships
Leishmaniasis is a parasitic neglected tropical disease caused by various species of
Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug …
Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug …
Novel bis-benzimidazole-triazole hybrids: anticancer study, in silico approaches, and mechanistic investigation
Aim Benzimidazole-triazole conjugates are very active hotspot for design and synthesis of
promising anticancer agents. The target analogs showed potent and selective cytotoxicity …
promising anticancer agents. The target analogs showed potent and selective cytotoxicity …
Structure based designing of benzimidazole/benzoxazole derivatives as anti-leishmanial agents
Folates are essential biomolecules required to carry out many crucial processes in
leishmania parasite. Dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine …
leishmania parasite. Dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine …
[HTML][HTML] State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis
V Francesconi, M Rizzo, S Schenone… - Current Medicinal …, 2024 - ncbi.nlm.nih.gov
Protozoan parasites represent a significant risk for public health worldwide, afflicting
particularly people in more vulnerable categories and cause large morbidity and heavy …
particularly people in more vulnerable categories and cause large morbidity and heavy …
The azoles in pharmacochemistry: Perspectives on the synthesis of new compounds and chemoinformatic contributions
J de Oliveira Viana, AFM Monteiro… - Current …, 2019 - ingentaconnect.com
Due to their versatile biological activity, Azoles are widely studied in pharmacochemistry. It is
possible to use them in many applications and in studies aimed at discovering antiparasitic …
possible to use them in many applications and in studies aimed at discovering antiparasitic …
Compounds with potentialities as novel chemotherapeutic agents in leishmaniasis at preclinical level
M González-Matos, ME Aguado, M Izquierdo… - Experimental …, 2024 - Elsevier
Leishmaniasis are neglected infectious diseases caused by kinetoplastid protozoan
parasites from the genus Leishmania. These sicknesses are present mainly in tropical …
parasites from the genus Leishmania. These sicknesses are present mainly in tropical …
SYNTHESIS AND CRYSTAL STRUCTURE OF THE COBALT(II) COMPLEX WITH 1-{1-[2-(o- TOLYLOXY)ETHYL]-1H-BENZIMIDAZOLE-2-YL}ETHAN-1-OL
AS Burlov, LN Divaeva, VG Vlasenko… - Journal of Structural …, 2022 - Springer
A Co (II) complex with 1-{1-[2-(o-tolyloxy) ethyl]-1 H-benzimidazol-2-yl} ethan-1-ol is
prepared. It is established by elemental analysis and IR spectroscopy that the composition of …
prepared. It is established by elemental analysis and IR spectroscopy that the composition of …
Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery
Leishmaniasis is a group of neglected infectious diseases, with approximately 1. 3 million
new cases each year, for which the available therapies have serious limitations. Therefore, it …
new cases each year, for which the available therapies have serious limitations. Therefore, it …
A Critical Review on Recent Heterocyclics Identified for Anti-Leishmanial Therapy
Background: Leishmaniasis is a multifaceted disease that is prevalent worldwide. It is an
epidemic, tropical/subtropical disease caused by macrophage infection by compulsive …
epidemic, tropical/subtropical disease caused by macrophage infection by compulsive …