Drug discovery for cutaneous leishmaniasis: a review of developments in the past 15 years

HN Corman, CW McNamara, MA Bakowski - Microorganisms, 2023 - mdpi.com
Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …

Recent advancements in anti-leishmanial research: Synthetic strategies and structural activity relationships

O Gupta, T Pradhan, R Bhatia, V Monga - European Journal of Medicinal …, 2021 - Elsevier
Leishmaniasis is a parasitic neglected tropical disease caused by various species of
Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug …

Novel bis-benzimidazole-triazole hybrids: anticancer study, in silico approaches, and mechanistic investigation

MA Soliman, HEA Ahmed, EH Eltamany… - Future Medicinal …, 2025 - Taylor & Francis
Aim Benzimidazole-triazole conjugates are very active hotspot for design and synthesis of
promising anticancer agents. The target analogs showed potent and selective cytotoxicity …

Structure based designing of benzimidazole/benzoxazole derivatives as anti-leishmanial agents

S Kapil, PK Singh, A Kashyap… - SAR and QSAR in …, 2019 - Taylor & Francis
Folates are essential biomolecules required to carry out many crucial processes in
leishmania parasite. Dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine …

[HTML][HTML] State-of-the-art Review on the Antiparasitic Activity of Benzimidazole-based Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis

V Francesconi, M Rizzo, S Schenone… - Current Medicinal …, 2024 - ncbi.nlm.nih.gov
Protozoan parasites represent a significant risk for public health worldwide, afflicting
particularly people in more vulnerable categories and cause large morbidity and heavy …

The azoles in pharmacochemistry: Perspectives on the synthesis of new compounds and chemoinformatic contributions

J de Oliveira Viana, AFM Monteiro… - Current …, 2019 - ingentaconnect.com
Due to their versatile biological activity, Azoles are widely studied in pharmacochemistry. It is
possible to use them in many applications and in studies aimed at discovering antiparasitic …

Compounds with potentialities as novel chemotherapeutic agents in leishmaniasis at preclinical level

M González-Matos, ME Aguado, M Izquierdo… - Experimental …, 2024 - Elsevier
Leishmaniasis are neglected infectious diseases caused by kinetoplastid protozoan
parasites from the genus Leishmania. These sicknesses are present mainly in tropical …

SYNTHESIS AND CRYSTAL STRUCTURE OF THE COBALT(II) COMPLEX WITH 1-{1-[2-(o- TOLYLOXY)ETHYL]-1H-BENZIMIDAZOLE-2-YL}ETHAN-1-OL

AS Burlov, LN Divaeva, VG Vlasenko… - Journal of Structural …, 2022 - Springer
A Co (II) complex with 1-{1-[2-(o-tolyloxy) ethyl]-1 H-benzimidazol-2-yl} ethan-1-ol is
prepared. It is established by elemental analysis and IR spectroscopy that the composition of …

Systematic in silico Evaluation of Leishmania spp. Proteomes for Drug Discovery

CR dos Santos Vasconcelos, AM Rezende - Frontiers in Chemistry, 2021 - frontiersin.org
Leishmaniasis is a group of neglected infectious diseases, with approximately 1. 3 million
new cases each year, for which the available therapies have serious limitations. Therefore, it …

A Critical Review on Recent Heterocyclics Identified for Anti-Leishmanial Therapy

S Rathore, A Sahu, RK Agrawal… - Current Chemical …, 2022 - ingentaconnect.com
Background: Leishmaniasis is a multifaceted disease that is prevalent worldwide. It is an
epidemic, tropical/subtropical disease caused by macrophage infection by compulsive …