Nearly a century after the significance of the human complement system was recognized, we
have come to realize that its functions extend far beyond the elimination of microbes …

The complement system consists of a tightly regulated network of proteins that play an
important role in host defense and inflammation. Complement activation results in …

The parallel expression of activation products of the coagulation, fibrinolysis, and
complement systems has long been observed in both clinical and experimental settings …

The convergence between complement and the clotting system extends far beyond the
chemical nature of the complement and coagulation components, both of which form …

Persistent inflammation is known to promote and exacerbate malignancy. Primary liver
cancer, mostly hepatocellular carcinoma (HCC), is a clear example of inflammation-related …

A connection between inflammation and cancer has been long suspected. Epidemiological
studies have established that many tumors occur in association with chronic infectious …

Self-non-self discrimination has long been considered the main function of the immune
system. Increasing evidence supports the view of the immune system as a network of …

Several studies of human cancers have established that chronic and insidious inflammation
promotes the process of carcinogenesis and exacerbates the growth of existing tumors …

The liver is a preferred target organ for gene therapy not only for liver-specific diseases but
also for disorders that require systemic delivery of a protein. Diseases that could benefit from …

Epidemiological studies have established that many tumours occur in association with
persistent inflammation. One clear example of inflammation-related cancer is hepatocellular …