Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms
Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …
Internalization mechanisms of cell-penetrating peptides
I Ruseska, A Zimmer - Beilstein journal of nanotechnology, 2020 - beilstein-journals.org
In today's modern era of medicine, macromolecular compounds such as proteins, peptides
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …
and nucleic acids are dethroning small molecules as leading therapeutics. Given their …
Tumor penetrating peptides for improved drug delivery
E Ruoslahti - Advanced drug delivery reviews, 2017 - Elsevier
In vivo screening of phage libraries in tumor-bearing mice has been used to identify
peptides that direct phage homing to a tumor. The power of in vivo phage screening is …
peptides that direct phage homing to a tumor. The power of in vivo phage screening is …
StackCPPred: a stacking and pairwise energy content-based prediction of cell-penetrating peptides and their uptake efficiency
Abstract Motivation Cell-penetrating peptides (CPPs) are a vehicle for transporting into living
cells pharmacologically active molecules, such as short interfering RNAs, nanoparticles …
cells pharmacologically active molecules, such as short interfering RNAs, nanoparticles …
Uses and abuses of macropinocytosis
G Bloomfield, RR Kay - Journal of cell science, 2016 - journals.biologists.com
Macropinocytosis is a means by which eukaryotic cells ingest extracellular liquid and
dissolved molecules. It is widely conserved amongst cells that can take on amoeboid form …
dissolved molecules. It is widely conserved amongst cells that can take on amoeboid form …
Tumor‐triggered disassembly of a multiple‐agent‐therapy probe for efficient cellular internalization
J Yang, J Dai, Q Wang, Y Cheng, J Guo… - Angewandte …, 2020 - Wiley Online Library
Integration of multiple agent therapy (MAT) into one probe is promising for improving
therapeutic efficiency for cancer treatment. However, MAT probe, if entering the cell as a …
therapeutic efficiency for cancer treatment. However, MAT probe, if entering the cell as a …
Cell-penetrating peptides to enhance delivery of oligonucleotide-based therapeutics
The promise of nucleic acid based oligonucleotides as effective genetic therapies has been
held back by their low bioavailability and poor cellular uptake to target tissues upon systemic …
held back by their low bioavailability and poor cellular uptake to target tissues upon systemic …
Redesigning of cell-penetrating peptides to improve their efficacy as a drug delivery system
Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …
compounds into cells. Since the discovery of the first members of this peptide family, many …
Strategies for delivering nanoparticles across tumor blood vessels
Nanoparticle transport across tumor blood vessels is a key step in nanoparticle delivery to
solid tumors. However, the specific pathways and mechanisms of this nanoparticle delivery …
solid tumors. However, the specific pathways and mechanisms of this nanoparticle delivery …
Basic physicochemical properties of polyethylene glycol coated gold nanoparticles that determine their interaction with cells
A homologous nanoparticle library was synthesized in which gold nanoparticles were
coated with polyethylene glycol, whereby the diameter of the gold cores, as well as the …
coated with polyethylene glycol, whereby the diameter of the gold cores, as well as the …