Alzheimer's disease as a synaptopathy: Evidence for dysfunction of synapses during disease progression

S Meftah, J Gan - Frontiers in Synaptic Neuroscience, 2023 - frontiersin.org
The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Cortical excitability and plasticity in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis of transcranial magnetic stimulation …

Y Chou, M Sundman, VT That, J Green… - Ageing research reviews, 2022 - Elsevier
Background Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation
technique. When stimulation is applied over the primary motor cortex and coupled with …

Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

Y Mimura, H Nishida, S Nakajima, S Tsugawa… - Neuroscience & …, 2021 - Elsevier
Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that
enables the investigation of cortical excitability in the human brain. Paired-pulse TMS …

Epilepsy and Alzheimer's Disease: Potential mechanisms for an association

FS Giorgi, LF Saccaro, CL Busceti, F Biagioni… - Brain Research …, 2020 - Elsevier
Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …

Seizures in Alzheimer's disease are highly recurrent and associated with a poor disease course

J Vöglein, I Ricard, S Noachtar, WA Kukull… - Journal of …, 2020 - Springer
Background Seizures are an important comorbidity in Alzheimer's disease (AD). Conflicting
results regarding clinical parameters associated with seizures in AD were previously …

The hippocampus associated GABAergic neural network impairment in early-stage of Alzheimer's disease

Y Tang, Y Yan, J Mao, J Ni, H Qing - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) is the commonest neurodegenerative disease with slow
progression. Pieces of evidence suggest that the GABAergic system is impaired in the early …

Mechanisms involved in epileptogenesis in Alzheimer's disease and their therapeutic implications

M Altuna, G Olmedo-Saura, M Carmona-Iragui… - International journal of …, 2022 - mdpi.com
Epilepsy and Alzheimer's disease (AD) incidence increases with age. There are reciprocal
relationships between epilepsy and AD. Epilepsy is a risk factor for AD and, in turn, AD is an …

[HTML][HTML] EEG window length evaluation for the detection of Alzheimer's disease over different brain regions

KD Tzimourta, N Giannakeas, AT Tzallas, LG Astrakas… - Brain sciences, 2019 - mdpi.com
Alzheimer's Disease (AD) is a neurogenerative disorder and the most common type of
dementia with a rapidly increasing world prevalence. In this paper, the ability of several …

Central role for NMDA receptors in redox mediated impairment of synaptic function during aging and Alzheimer's disease

TC Foster, C Kyritsopoulos, A Kumar - Behavioural brain research, 2017 - Elsevier
Increased human longevity has magnified the negative impact that aging can have on
cognitive integrity of older individuals experiencing some decline in cognitive function …

Amyloid β causes excitation/inhibition imbalance through dopamine receptor 1-dependent disruption of fast-spiking GABAergic input in anterior cingulate cortex

SQ Ren, W Yao, JZ Yan, C **, JJ Yin, J Yuan, S Yu… - Scientific reports, 2018 - nature.com
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. At the early
stages of AD development, the soluble β-amyloid (Aβ) induces synaptic dysfunction …