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RNA m6A methylation across the transcriptome
Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets
J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …
The roles and implications of RNA m6A modification in cancer
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …
Biological roles of adenine methylation in RNA
K Boulias, EL Greer - Nature Reviews Genetics, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …
RNA modifications: importance in immune cell biology and related diseases
L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …
including generation, transportation, function, and metabolization, they act as critical …
Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination
Abstract N 6-methyladenosine (m6A), the most abundant internal messenger RNA
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
modification in higher eukaryotes, serves myriad roles in regulating cellular processes …
Epigenetic modification of m6A regulator proteins in cancer
Abstract Divergent N6-methyladenosine (m6A) modifications are dynamic and reversible
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
posttranscriptional RNA modifications that are mediated by m6A regulators or m6A RNA …
A comprehensive review of m6A/m6Am RNA methyltransferase structures
S Oerum, V Meynier, M Catala, C Tisné - Nucleic acids research, 2021 - academic.oup.com
Gene expression is regulated at many levels including co-or post-transcriptionally, where
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
chemical modifications are added to RNA on riboses and bases. Expression control via RNA …
Ribosome biogenesis factors—from names to functions
K Dörner, C Ruggeri, I Zemp, U Kutay - The EMBO journal, 2023 - embopress.org
The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …
RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy
WW Liu, SQ Zheng, T Li, YF Fei, C Wang… - Signal transduction and …, 2024 - nature.com
Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis
requirements of cells. Relevant studies have been constantly making inroads in our …
requirements of cells. Relevant studies have been constantly making inroads in our …