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Recent developments in antimalarial drug discovery
T Umumararungu, JB Nkuranga, G Habarurema… - Bioorganic & Medicinal …, 2023 - Elsevier
Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …
economic stability, particularly in the countries where malaria is endemic, there have been …
Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances
Nanotechnology has attracted researchers around the globe owing to the small size and
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …
Development and evaluation of self-microemulsifying drug delivery system for improving oral absorption of poorly water-soluble olaparib
YH Kim, SB Kim, SH Choi, TTL Nguyen, SH Ahn… - Pharmaceutics, 2023 - mdpi.com
The purpose of this study is to develop and evaluate a self-microemulsifying drug delivery
system (SMEDDS) to improve the oral absorption of poorly water-soluble olaparib. Through …
system (SMEDDS) to improve the oral absorption of poorly water-soluble olaparib. Through …
Synthesis and characterization of dimeric artesunate glycerol monocaprylate conjugate and formulation of nanoemulsion preconcentrate
Malaria is one of the major life-threatening health problems worldwide. Artesunate is the
most potent antimalarial drug to combat severe malaria. However, development of drug …
most potent antimalarial drug to combat severe malaria. However, development of drug …
Applicability of redirecting artemisinins for new targets
J Golenser, NH Hunt, I Birman, CL Jaffe… - Global …, 2023 - Wiley Online Library
Employing new therapeutic indications for drugs that are already approved for human use
has obvious advantages, including reduced costs and timelines, because some routine …
has obvious advantages, including reduced costs and timelines, because some routine …
Efficient treatment of experimental cerebral malaria by an artemisone-SMEDDS system: impact of application route and dosing frequency
Artemisone (ART) has been successfully tested in vitro and in animal models against
several diseases. However, its poor aqueous solubility and limited chemical stability are …
several diseases. However, its poor aqueous solubility and limited chemical stability are …
[HTML][HTML] Transdermal delivery of artemisinins for treatment of pre-clinical cerebral malaria
Transdermal drug delivery avoids complications related to oral or parenteral delivery-the
need for sterility, contamination, gastrointestinal side effects, patient unconsciousness or …
need for sterility, contamination, gastrointestinal side effects, patient unconsciousness or …
Meeting the Needs of a Potent Carrier for Malaria Treatment: Encapsulation of Artemisone in Poly(lactide‐co‐glycolide) Micro‐ and Nanoparticles
M Heidari, J Golenser, A Greiner - Particle & Particle Systems …, 2022 - Wiley Online Library
Biodegradable polymer nano‐and microparticles are of interest as drug carriers due to their
capability to modulate drug release. Two different methods, including solvent displacement …
capability to modulate drug release. Two different methods, including solvent displacement …
Considering ivermectin for treatment of schistosomiasis
J Golenser, I Birman, D Gold - Parasitology Research, 2024 - Springer
Because of recent reports of praziquantel resistance in schistosome infections, there have
been suggestions to employ ivermectin as a possible alternative, especially as its chemical …
been suggestions to employ ivermectin as a possible alternative, especially as its chemical …
Safety evaluation of curcumol by a repeated dose 28-day oral exposure toxicity study in rats
Z Yang, S Wang, Y Hong, R Gai, W Hong, B Tang… - Toxics, 2023 - mdpi.com
Curcumol, a natural product isolated from the traditional Chinese medicine Rhizoma
curcumae, possesses various potential therapeutic values in many diseases. However …
curcumae, possesses various potential therapeutic values in many diseases. However …