Recent developments in antimalarial drug discovery

T Umumararungu, JB Nkuranga, G Habarurema… - Bioorganic & Medicinal …, 2023 - Elsevier
Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …

Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances

R Verma, V Mittal, P Pandey, S Bhatia… - Current Drug …, 2023 - benthamdirect.com
Nanotechnology has attracted researchers around the globe owing to the small size and
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …

Development and evaluation of self-microemulsifying drug delivery system for improving oral absorption of poorly water-soluble olaparib

YH Kim, SB Kim, SH Choi, TTL Nguyen, SH Ahn… - Pharmaceutics, 2023 - mdpi.com
The purpose of this study is to develop and evaluate a self-microemulsifying drug delivery
system (SMEDDS) to improve the oral absorption of poorly water-soluble olaparib. Through …

Synthesis and characterization of dimeric artesunate glycerol monocaprylate conjugate and formulation of nanoemulsion preconcentrate

R Hore, N Hasan, K Mäder, J Kressler - Molecules, 2023 - mdpi.com
Malaria is one of the major life-threatening health problems worldwide. Artesunate is the
most potent antimalarial drug to combat severe malaria. However, development of drug …

Applicability of redirecting artemisinins for new targets

J Golenser, NH Hunt, I Birman, CL Jaffe… - Global …, 2023 - Wiley Online Library
Employing new therapeutic indications for drugs that are already approved for human use
has obvious advantages, including reduced costs and timelines, because some routine …

Efficient treatment of experimental cerebral malaria by an artemisone-SMEDDS system: impact of application route and dosing frequency

J Zech, N Salaymeh, NH Hunt, K Mäder… - Antimicrobial agents …, 2021 - journals.asm.org
Artemisone (ART) has been successfully tested in vitro and in animal models against
several diseases. However, its poor aqueous solubility and limited chemical stability are …

[HTML][HTML] Transdermal delivery of artemisinins for treatment of pre-clinical cerebral malaria

J Zech, R Dzikowski, K Simantov, J Golenser… - International Journal for …, 2021 - Elsevier
Transdermal drug delivery avoids complications related to oral or parenteral delivery-the
need for sterility, contamination, gastrointestinal side effects, patient unconsciousness or …

Meeting the Needs of a Potent Carrier for Malaria Treatment: Encapsulation of Artemisone in Poly(lactide‐co‐glycolide) Micro‐ and Nanoparticles

M Heidari, J Golenser, A Greiner - Particle & Particle Systems …, 2022 - Wiley Online Library
Biodegradable polymer nano‐and microparticles are of interest as drug carriers due to their
capability to modulate drug release. Two different methods, including solvent displacement …

Considering ivermectin for treatment of schistosomiasis

J Golenser, I Birman, D Gold - Parasitology Research, 2024 - Springer
Because of recent reports of praziquantel resistance in schistosome infections, there have
been suggestions to employ ivermectin as a possible alternative, especially as its chemical …

Safety evaluation of curcumol by a repeated dose 28-day oral exposure toxicity study in rats

Z Yang, S Wang, Y Hong, R Gai, W Hong, B Tang… - Toxics, 2023 - mdpi.com
Curcumol, a natural product isolated from the traditional Chinese medicine Rhizoma
curcumae, possesses various potential therapeutic values in many diseases. However …