Recent developments in tubulin polymerization inhibitors: an overview
Microtubules are protein biopolymers formed through polymerization of heterodimers of α-
and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G 2-M phase and …
and β-tubulins. Disruption of microtubules can induce cell cycle arrest in G 2-M phase and …
Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures
The vital roles of microtubule in mitosis and cell division make it an attractive target for
antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that …
antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that …
Cobalt-catalyzed enantioselective hydrogenation of minimally functionalized alkenes: isotopic labeling provides insight into the origin of stereoselectivity and alkene …
The asymmetric hydrogenation of cyclic alkenes lacking coordinating functionality with a C 1-
symmetric bis (imino) pyridine cobalt catalyst is described and has been applied to the …
symmetric bis (imino) pyridine cobalt catalyst is described and has been applied to the …
Feedstocks to pharmacophores: Cu-catalyzed oxidative arylation of inexpensive alkylarenes enabling direct access to diarylalkanes
A Vasilopoulos, SL Zultanski… - Journal of the American …, 2017 - ACS Publications
A Cu-catalyzed method has been identified for selective oxidative arylation of benzylic C–H
bonds with arylboronic esters. The resulting 1, 1-diarylalkanes are accessed directly from …
bonds with arylboronic esters. The resulting 1, 1-diarylalkanes are accessed directly from …
Ligand-controlled nickel-catalyzed reductive relay cross-coupling of alkyl bromides and aryl bromides
1, 1-Diarylalkanes are important structural frameworks which are widespread in biologically
active molecules. Herein, we report a reductive relay cross-coupling of alkyl bromides with …
active molecules. Herein, we report a reductive relay cross-coupling of alkyl bromides with …
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site
A series of novel isocombretastatin A-4 (isoCA-4) analogs were designed and synthesized
by replacing 3, 4, 5-trimethoylphenyl and isovanillin of isoCA-4 with quinoline and indole …
by replacing 3, 4, 5-trimethoylphenyl and isovanillin of isoCA-4 with quinoline and indole …
Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents
Abstract New thiosemicarbazone derivatives (1–10) were obtained via the reaction of 4-
(naphthalen-1-yl) thiosemicarbazide with fluoro-substituted aromatic aldehydes. The …
(naphthalen-1-yl) thiosemicarbazide with fluoro-substituted aromatic aldehydes. The …
Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors
I Khelifi, T Naret, D Renko, A Hamze, G Bernadat… - European journal of …, 2017 - Elsevier
The synthesis and evaluation of a new series of IsoCombretaQuinolines (IsoCoQuines) 2
with a 2-substituted-quinoline in place of the 3, 4, 5-trimethoxyphenyl ring present in isoCA-4 …
with a 2-substituted-quinoline in place of the 3, 4, 5-trimethoxyphenyl ring present in isoCA-4 …
One-pot synthesis of thiazolo [3, 2-a] pyrimidine derivatives, their cytotoxic evaluation and molecular docking studies
T Sekhar, P Thriveni, A Venkateswarlu… - … Acta Part A: Molecular …, 2020 - Elsevier
An economical, simple and efficient one-pot method has been developed for the synthesis of
thiazolo [3, 2-a] pyrimidine hydrobromide derivatives. 2, 4-diaryl-6, 7, 8, 9-tetrahydro-4 H …
thiazolo [3, 2-a] pyrimidine hydrobromide derivatives. 2, 4-diaryl-6, 7, 8, 9-tetrahydro-4 H …
Synthesis, biological evaluation and molecular docking studies of a new series of chalcones containing naphthalene moiety as anticancer agents
G Wang, J Qiu, X **ao, A Cao, F Zhou - Bioorganic Chemistry, 2018 - Elsevier
A series of chalcones containing naphthalene moiety 4a–4p have been synthesized,
characterized by 1 H NMR and 13 C NMR and evaluated for their in vitro anticancer activity …
characterized by 1 H NMR and 13 C NMR and evaluated for their in vitro anticancer activity …