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The blood–brain barrier: Structure, regulation and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …
[HTML][HTML] The bioavailability of drugs—the current state of knowledge
M Stielow, A Witczyńska, N Kubryń, Ł Fijałkowski… - Molecules, 2023 - mdpi.com
Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug
therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in …
therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in …
[HTML][HTML] Current strategies for exosome cargo loading and targeting delivery
Extracellular vesicles (EVs) such as ectosomes and exosomes have gained attention as
promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in …
promising natural carriers for drug delivery. Exosomes, which range from 30 to 100 nm in …
Functionalized nanomaterials capable of crossing the blood–brain barrier
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly
regulates exchanges between the central nervous system parenchyma and blood vessels …
regulates exchanges between the central nervous system parenchyma and blood vessels …
Immune exosomes loading self-assembled nanomicelles traverse the blood–brain barrier for chemo-immunotherapy against glioblastoma
J Cui, X Wang, J Li, A Zhu, Y Du, W Zeng, Y Guo, L Di… - ACS …, 2023 - ACS Publications
Effective drug delivery and prevention of postoperative recurrence are significant challenges
for current glioblastoma (GBM) treatment. Poor drug delivery is mainly due to the presence …
for current glioblastoma (GBM) treatment. Poor drug delivery is mainly due to the presence …
Precision drug delivery to the central nervous system using engineered nanoparticles
Abstract Development of novel therapies for central nervous system (CNS) disorders has
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
experienced a high failure rate in clinical trials owing to unsatisfactory efficacy and adverse …
Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy
We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling,
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …
noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe …
Roles of exosomes in immunotherapy for solid cancers
C Lyu, H Sun, Z Sun, Y Liu, Q Wang - Cell Death & Disease, 2024 - nature.com
Although immunotherapy has made breakthrough progress, its efficacy in solid tumours
remains unsatisfactory. Exosomes are the main type of extracellular vesicles that can deliver …
remains unsatisfactory. Exosomes are the main type of extracellular vesicles that can deliver …
Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to …
The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
Pathophysiology of blood–brain barrier permeability throughout the different stages of ischemic stroke and its implication on hemorrhagic transformation and recovery
The blood–brain barrier (BBB) is a dynamic interface responsible for maintaining the central
nervous system homeostasis. Its unique characteristics allow protecting the brain from …
nervous system homeostasis. Its unique characteristics allow protecting the brain from …