T cell receptor (TCR) signaling in health and disease
Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
changes at the molecular and cellular levels in T cells. The outside environmental cues are …
Cellular functions regulated by Src family kinases
SM Thomas, JS Brugge - Annual review of cell and …, 1997 - annualreviews.org
▪ Abstract Src family protein tyrosine kinases are activated following engagement of many
different classes of cellular receptors and participate in signaling pathways that control a …
different classes of cellular receptors and participate in signaling pathways that control a …
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation
EH Palacios, A Weiss - Oncogene, 2004 - nature.com
The function of the Src-family kinases (SFKs) Lck and Fyn in T cells has been intensively
studied over the past 15 years. Animal models and cell line studies both indicate a critical …
studied over the past 15 years. Animal models and cell line studies both indicate a critical …
Insights into the initiation of TCR signaling
AK Chakraborty, A Weiss - Nature immunology, 2014 - nature.com
The initiation of T cell antigen receptor signaling is a key step that can result in T cell
activation and the orchestration of an adaptive immune response. Early events in T cell …
activation and the orchestration of an adaptive immune response. Early events in T cell …
The TIM3/Gal9 signaling pathway: An emerging target for cancer immunotherapy
Immune checkpoint blockade has shown unprecedented and durable clinical response in a
wide range of cancers. T cell immunoglobulin and mucin domain 3 (TIM3) is an inhibitory …
wide range of cancers. T cell immunoglobulin and mucin domain 3 (TIM3) is an inhibitory …
A critical role for Syk in signal transduction and phagocytosis mediated by Fcγ receptors on macrophages
MT Crowley, PS Costello, CJ Fitzer-Attas… - The Journal of …, 1997 - rupress.org
Receptors on macrophages for the Fc region of IgG (FcγR) mediate a number of responses
important for host immunity. Signaling events necessary for these responses are likely …
important for host immunity. Signaling events necessary for these responses are likely …
Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists
C Stahn, M Löwenberg, DW Hommes… - Molecular and cellular …, 2007 - Elsevier
Glucocorticoids (GC) are the most common used anti-inflammatory and immunosuppressive
drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic …
drugs in the treatment of rheumatic and other inflammatory diseases. Their therapeutic …
T‐cell receptor proximal signaling via the Src‐family kinases, Lck and Fyn, influences T‐cell activation, differentiation, and tolerance
T‐cell development in the thymus and activation of mature T cells in secondary lymphoid
organs requires the ability of cells to respond appropriately to environmental signals at …
organs requires the ability of cells to respond appropriately to environmental signals at …
Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell–antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck
and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus leading to the …
and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, thus leading to the …
[HTML][HTML] Engagement of T cell receptor triggers its recruitment to low‐density detergent‐insoluble membrane domains
C Montixi, C Langlet, AM Bernard, J Thimonier… - The EMBO …, 1998 - embopress.org
T‐cell receptors (TCRs) upon binding to peptide–MHC ligands transduce signals in T
lymphocytes. Tyrosine phosphorylations in the cytoplasmic domains of the CD3 (γδϵ) and ζ …
lymphocytes. Tyrosine phosphorylations in the cytoplasmic domains of the CD3 (γδϵ) and ζ …