Ghrelin, an endogenous brain–gut peptide, is secreted in large quantities, mainly from the
stomach, in humans and rodents. It can perform the biological function of activating the …

Eating behaviors are influenced by the reinforcing properties of foods that can favor
decisions driven by reward incentives over metabolic needs. These food reward-motivated …

High-fat diet (HFD) consumption leads to obesity and a chronic state of low-grade
inflammation, named metainflammation. Notably, metainflammation contributes to …

The growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor
(GPCR) highly expressed in the brain, and also in some peripheral tissues. GHSR activity is …

Ghrelin is a peptide hormone released by specialized X/A cells in the stomach and activated
by acylation. Following its secretion, it binds to ghrelin receptors in the periphery to regulate …

Ghrelin is a gut peptide hormone associated with feeding behavior and energy homeostasis.
Acylated ghrelin binds to the growth hormone secretagogue receptor 1a subtype (GHS-R1a) …

Major depressive disorder (MDD) constitutes a challenge in the field of mental disorders,
given its high prevalence in the general population and its impact on the quality of life, while …

Obesity before and during pregnancy negatively affects the mental and physical health of
the mother. A diet high in fat also increases the risk for anxiety, depression and cognitive …

The orexigenic hormone ghrelin is being increasingly recognized as a stress hormone being
involved in anxiety regulation. In animals, ghrelin effects on, and responses to acute stress …

Neuromedin U (NMU) is an evolutionary conserved neuropeptide that has been implicated
in multiple processes, such as circadian regulation, energy homeostasis, reward processing …