Multimorbidity

ST Skou, FS Mair, M Fortin, B Guthrie… - Nature Reviews …, 2022 - nature.com
Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Biological and functional multimorbidity—from mechanisms to management

C Langenberg, AD Hingorani, CJM Whitty - Nature Medicine, 2023 - nature.com
Globally, the number of people with multiple co-occurring diseases will increase
substantially over the coming decades, with important consequences for patients, carers …

Diabetes and multiple long-term conditions: A review of our current global health challenge

K Khunti, YV Chudasama, EW Gregg… - Diabetes …, 2023 - Am Diabetes Assoc
Use of effective treatments and management programs is leading to longer survival of
people with diabetes. This, in combination with obesity, is thus contributing to a rise in …

The impact of adverse childhood experiences on multimorbidity: a systematic review and meta-analysis

DNS Senaratne, B Thakkar, BH Smith, TG Hales… - BMC medicine, 2024 - Springer
Abstract Background Adverse childhood experiences (ACEs) have been implicated in the
aetiology of a range of health outcomes, including multimorbidity. In this systematic review …

Overweight, obesity and risk of multimorbidity: a systematic review and meta‐analysis of longitudinal studies

FM Delpino, AP dos Santos Rodrigues… - Obesity …, 2023 - Wiley Online Library
This study aimed to review and quantify the association between overweight and obesity in
the risk of multimorbidity among the general population. We conducted a systematic review …

Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records

RA Baksh, SE Pape, LF Chan, AA Aslam… - The Lancet Public …, 2023 - thelancet.com
Summary Background The Down syndrome phenotype is well established, but our
understanding of its morbidity patterns is limited. We comprehensively estimated the risk of …

The impact of varying the number and selection of conditions on estimated multimorbidity prevalence: a cross-sectional study using a large, primary care population …

C MacRae, M McMinn, SW Mercer, D Henderson… - PLoS …, 2023 - journals.plos.org
Background Multimorbidity prevalence rates vary considerably depending on the conditions
considered in the morbidity count, but there is no standardised approach to the number or …

Age, sex, and socioeconomic differences in multimorbidity measured in four ways: UK primary care cross-sectional analysis

C MacRae, SW Mercer, D Henderson… - British Journal of …, 2023 - bjgp.org
Background Multimorbidity poses major challenges to healthcare systems worldwide.
Definitions with cut-offs in excess of≥ 2 long-term conditions (LTCs) might better capture …

Ethnic differences in early onset multimorbidity and associations with health service use, long-term prescribing, years of life lost, and mortality: A cross-sectional study …

F Eto, M Samuel, R Henkin, M Mahesh, T Ahmad… - PLoS …, 2023 - journals.plos.org
Background The population prevalence of multimorbidity (the existence of at least 2 or more
long-term conditions [LTCs] in an individual) is increasing among young adults, particularly …

Prevalence of multiple long-term conditions (multimorbidity) in England: a whole population study of over 60 million people

J Valabhji, E Barron, A Pratt… - Journal of the Royal …, 2024 - journals.sagepub.com
Objectives To determine the prevalence of multiple long-term conditions (MLTC) at whole
English population level, stratifying by age, sex, socioeconomic status and ethnicity. Design …