Non-viral vectors in gene therapy: recent development, challenges, and prospects

H Zu, D Gao - The AAPS journal, 2021 - Springer
Gene therapy has been experiencing a breakthrough in recent years, targeting various
specific cell groups in numerous therapeutic areas. However, most recent clinical studies …

Biopolymers based aerogels: A review on revolutionary solutions for smart therapeutics delivery

HPSA Khalil, EB Yahya, F Jummaat, AS Adnan… - Progress in Materials …, 2023 - Elsevier
Biopolymers-based aerogels have gained the attention of many scientists in medical and
pharmaceutical applications. Biopolymers-based aerogels are utilized extensively in the …

[HTML][HTML] Polyethylenimine (PEI) in gene therapy: Current status and clinical applications

J Casper, SH Schenk, E Parhizkar, P Detampel… - Journal of Controlled …, 2023 - Elsevier
Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

Cationic polysaccharide conjugates as antibiotic adjuvants resensitize multidrug‐resistant bacteria and prevent resistance

S Mu, Y Zhu, Y Wang, S Qu, Y Huang… - Advanced …, 2022 - Wiley Online Library
In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of
multidrug‐resistant (MDR) bacteria, which poses severe threat to human life and globalized …

[HTML][HTML] Polymeric delivery systems for nucleic acid therapeutics: Approaching the clinic

AIS van den Berg, CO Yun, RM Schiffelers… - Journal of Controlled …, 2021 - Elsevier
Gene therapy using nucleic acids has many clinical applications for the treatment of
diseases with a genetic origin as well as for the development of innovative vaccine …

Targeted delivery of drugs and genes using polymer nanocarriers for cancer therapy

W **a, Z Tao, B Zhu, W Zhang, C Liu, S Chen… - International journal of …, 2021 - mdpi.com
Cancer is one of the primary causes of worldwide human deaths. Most cancer patients
receive chemotherapy and radiotherapy, but these treatments are usually only partially …

Degradable polymeric bio (nano) materials and their biomedical applications: A comprehensive overview and recent updates

K Kuperkar, LI Atanase, A Bahadur, IC Crivei… - Polymers, 2024 - mdpi.com
Degradable polymers (both biomacromolecules and several synthetic polymers) for
biomedical applications have been promising very much in the recent past due to their low …

[HTML][HTML] Biodegradable polymeric nanoparticle-based drug delivery systems: comprehensive overview, perspectives and challenges

M Geszke-Moritz, M Moritz - Polymers, 2024 - mdpi.com
In the last few decades, there has been a growing interest in the use of biodegradable
polymeric nanoparticles (BPNPs) as the carriers for various therapeutic agents in drug …

Current-status and applications of polysaccharides in drug delivery systems

P Prasher, M Sharma, M Mehta, S Satija… - Colloid and Interface …, 2021 - Elsevier
The polysaccharide-based advanced drug delivery system owing to their biocompatibility,
ability to encapsulate the drug molecules in their interspaces, and ability to achieve a …

Amino acid derived biopolymers: Recent advances and biomedical applications

SS Gupta, V Mishra, MD Mukherjee, P Saini… - International Journal of …, 2021 - Elsevier
Over the past few years, amino acids (AA) have emerged as promising biomaterials for the
synthesis of functional polymers. Owing to the diversity of functional groups in amino acids …