The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
Inhibition of lipopolysaccharide-and lipoprotein-induced inflammation by antitoxin peptide Pep19-2.5
L Heinbockel, G Weindl, G Martinez-de-Tejada… - Frontiers in …, 2018 - frontiersin.org
The most potent cell wall-derived inflammatory toxins (“pathogenicity factors”) of Gram-
negative and-positive bacteria are lipopolysaccharides (LPS)(endotoxins) and lipoproteins …
negative and-positive bacteria are lipopolysaccharides (LPS)(endotoxins) and lipoproteins …
[HTML][HTML] Peptides with dual mode of action: Killing bacteria and preventing endotoxin-induced sepsis
K Brandenburg, L Heinbockel, W Correa… - Biochimica et Biophysica …, 2016 - Elsevier
Bacterial infections, with the most severe form being sepsis, can often not be treated
adequately leading to high morbidity and lethality of infected patients in critical care units. In …
adequately leading to high morbidity and lethality of infected patients in critical care units. In …
Innate Immune Responses of Galleria mellonella to Mycobacterium bovis BCG Challenge Identified Using Proteomic and Molecular Approaches
The larvae of the insect Galleria mellonella, have recently been established as a non-
mammalian infection model for the Mycobacterium tuberculosis complex (MTBC). To gain …
mammalian infection model for the Mycobacterium tuberculosis complex (MTBC). To gain …
Biophysical approaches for exploring lipopeptide-lipid interactions
In recent years, lipopeptides (LPs) have attracted a lot of attention in the pharmaceutical
industry due to their broad-spectrum of antimicrobial activity against a variety of pathogens …
industry due to their broad-spectrum of antimicrobial activity against a variety of pathogens …
Studies on the interactions of neutral Galleria mellonella cecropin D with living bacterial cells
A Zdybicka-Barabas, S Stączek… - Amino Acids, 2019 - Springer
Cecropins constitute an important family of insect antimicrobial peptides involved in humoral
innate immune response. In comparison with the highly basic cecropins A and B, cecropins …
innate immune response. In comparison with the highly basic cecropins A and B, cecropins …
A study of the interaction of a new benzimidazole schiff base with synthetic and simulated membrane models of bacterial and mammalian membranes
Biological membranes are complex dynamic systems composed of a great variety of
carbohydrates, lipids, and proteins, which together play a pivotal role in the protection of …
carbohydrates, lipids, and proteins, which together play a pivotal role in the protection of …
Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against Pseudomonas aeruginosa
Low molecular weight alginate oligosaccharides have been shown to exhibit anti-microbial
activity against a range of multi-drug resistant bacteria, including Pseudomonas aeruginosa …
activity against a range of multi-drug resistant bacteria, including Pseudomonas aeruginosa …
The increase in positively charged residues in cecropin D-like Galleria mellonella favors its interaction with membrane models that imitate bacterial membranes
A comparative study of three synthetic peptides, namely neutral Cecropin D-like G.
mellonella (WT) and two cationic peptides derived from its sequence, ΔM1 (+ 5) and ΔM2 (+ …
mellonella (WT) and two cationic peptides derived from its sequence, ΔM1 (+ 5) and ΔM2 (+ …
Studies on the interaction of alyteserin 1c peptide and its cationic analogue with model membranes imitating mammalian and bacterial membranes
Antimicrobial peptides (AMPs) are effector molecules of the innate immune system and have
been isolated from multiple organisms. Their antimicrobial properties are due to the fact that …
been isolated from multiple organisms. Their antimicrobial properties are due to the fact that …