Traditional classification of genetic diseases as monogenic and polygenic has lagged far
behind scientific progress. In this opinion article, we propose and define a new terminology …

Breast cancer exhibits various epigenetic abnormalities that regulate gene expression and
contribute to tumor characteristics. Epigenetic alterations play a significant role in cancer …

Cancer is one of the most widespread and severe diseases with a huge mortality rate. In
recent years, the second-leading mortality rate of any cancer globally has been breast …

Breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2
(BRCA2) deleterious variants were the first and, still today, the main biomarkers of poly …

ABSTRACT Formyl peptide receptor-1 (FPR1) is a pathogen recognition receptor involved in
the detection of bacteria, in the control of inflammation, as well as in cancer …

Breast cancer (BC) is the most common malignancy in American women.*, 1 Mortality has
declined, in part because screening detects cancers at an early stage. 2 For most women …

Breast cancer continues to be the most common cancer diagnosed among women
worldwide. Family history of breast cancer is frequently encountered, and 5-15% of patients …

Constitutional heterozygous mutations in CHEK2 gene have been associated with
hereditary cancer risk. To date, only a few homozygous CHEK2 mutations have been …

The detection of germline pathogenic variants (gPVs) in BRCA1/2 and other breast cancer
(BC) genes is rising exponentially thanks to the advent of multi-gene panel testing. This …

High-grade serous ovarian cancer (HGSOC) is the most lethal tumor of the female genital
tract. Despite extensive studies and the identification of some precursor lesions like serous …