The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

The blood–brain barrier (BBB) is a critical regulator of CNS homeostasis. It possesses
physical and biochemical characteristics (ie tight junction protein complexes, transporters) …

Stroke remains a major cause of long-term disability and mortality worldwide. The immune
system plays an important role in determining the condition of the brain following stroke. As …

This literature review focuses on the underlying pathophysiology of TBI and PTSD
symptoms, while also examining the plethora of stem cell treatment options to ameliorate …

Whether monocytes contribute to the brain microglial pool in development or after brain
injury remains contentious. To address this issue, we generated CCR2-CreER mice to track …

Brain ischemia affects all ages, from neonates to the elderly population, and is a leading
cause of mortality and morbidity. Multiple preclinical rodent models involving different ages …

Cerebral ischemia is a devastating condition that results in impaired blood flow in the brain
leading to acute brain injury. As the most common form of stroke, occlusion of cerebral …

Ischemic stroke and traumatic brain injury (TBI) comprise two particularly prevalent and
costly examples of acquired brain injury (ABI). Following stroke or TBI, primary cell death …

As an integral part of the innate immune system of the brain, resident microglia must react
rapidly to the onset of brain injury and neurological disease. These dynamic cells then …

Inhibition of histone deacetylases (HDACs) has been shown to reduce inflammation and
white matter damage after various forms of brain injury via modulation of …