Molecular insights and clinical implications for the tumor suppressor role of SCFFBXW7 E3 ubiquitin ligase
FBXW7 is one of the most well-characterized F-box proteins, serving as substrate receptor
subunit of SKP1-CUL1-F-box (SCF) E3 ligase complexes. SCF FBXW7 is responsible for the …
subunit of SKP1-CUL1-F-box (SCF) E3 ligase complexes. SCF FBXW7 is responsible for the …
Erythropoietin regulates energy metabolism through EPO-EpoR-RUNX1 axis
Erythropoietin (EPO) plays a key role in energy metabolism, with EPO receptor (EpoR)
expression in white adipose tissue (WAT) mediating its metabolic activity. Here, we show …
expression in white adipose tissue (WAT) mediating its metabolic activity. Here, we show …
FBXW7 in gastrointestinal cancers: from molecular mechanisms to therapeutic prospects
W Wang, X Liu, L Zhao, K Jiang, Z Yu… - Frontiers in …, 2024 - frontiersin.org
F-box and WD repeat domain-containing 7 (FBXW7), formerly known as hCdc4, hAGO
Fbw7, or SEL10, plays a specific recognition function in SCF-type E3 ubiquitin ligases …
Fbw7, or SEL10, plays a specific recognition function in SCF-type E3 ubiquitin ligases …
A germline point mutation in the MYC-FBW7 phosphodegron initiates hematopoietic malignancies
B Freie, PA Carroll, BJ Varnum-Finney… - Genes & …, 2024 - genesdev.cshlp.org
Oncogenic activation of MYC in cancers predominantly involves increased transcription
rather than coding region mutations. However, MYC-dependent lymphomas frequently …
rather than coding region mutations. However, MYC-dependent lymphomas frequently …
A virus-Packageable CRISPR system identifies host dependency factors Co-opted by multiple HIV-1 strains
VR Montoya, TM Ready, A Felton, SR Fine, M OhAinle… - Mbio, 2023 - journals.asm.org
At each stage of the HIV life cycle, host cellular proteins are hijacked by the virus to establish
and enhance infection. We adapted the virus packageable HIV-CRISPR screening …
and enhance infection. We adapted the virus packageable HIV-CRISPR screening …
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis
High‐risk endometrial cancer has poor prognosis and is increasing in incidence. However,
understanding of the molecular mechanisms which drive this disease is limited. We used …
understanding of the molecular mechanisms which drive this disease is limited. We used …
FBXW7 alleviates c-MYC repression of pyruvate carboxylase to support metabolic flexibility
Metabolic flexibility, or the ability to adapt to environmental fluctuations, is key to the survival
and growth of all living organisms. In mammals, the pathways supporting cell proliferation in …
and growth of all living organisms. In mammals, the pathways supporting cell proliferation in …
Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution
Somatic driver mutations, in genes such as FBXW7, have been discovered in phenotypically
normal colonic tissue, however their role in cancer initiation remains elusive. Here, using …
normal colonic tissue, however their role in cancer initiation remains elusive. Here, using …
A Virus-Packageable CRISPR System Identifies Host Dependency Factors Across Multiple HIV-1 Strains
VR Montoya, TM Ready, A Felton, SR Fine, M OhAinle… - bioRxiv, 2022 - biorxiv.org
At each stage of the HIV life cycle, host cellular proteins are hijacked by the virus to establish
and enhance infection. We adapted the virus packageable HIV-CRISPR screening …
and enhance infection. We adapted the virus packageable HIV-CRISPR screening …
Characterisation of the effect of FBXW7 mutations in normal and malignant colonic tissue
DKH Chan - 2023 - ora.ox.ac.uk
Colorectal cancer harbours significant intratumoral heterogeneity. Yet, while intratumoural
heterogeneity may be readily observed, events which give rise to heterogeneity, as well as …
heterogeneity may be readily observed, events which give rise to heterogeneity, as well as …