Streptomyces: The biofactory of secondary metabolites

K Alam, A Mazumder, S Sikdar, YM Zhao… - Frontiers in …, 2022 - frontiersin.org
Natural products derived from microorganisms serve as a vital resource of valuable
pharmaceuticals and therapeutic agents. Streptomyces is the most ubiquitous bacterial …

A review of gut microbiota‐derived metabolites in tumor progression and cancer therapy

Q Yang, B Wang, Q Zheng, H Li, X Meng… - Advanced …, 2023 - Wiley Online Library
Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer
progression, primarily by remodeling the tumor microenvironment and regulating key …

Microbiome—microbial metabolome—cancer cell interactions in breast cancer—familiar, but unexplored

E Mikó, T Kovács, É Sebő, J Tóth, T Csonka, G Ujlaki… - Cells, 2019 - mdpi.com
Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant
composition of the microbiome, characterizes breast cancer. In this review we discuss the …

Short-and long-read metagenomics of urban and rural South African gut microbiomes reveal a transitional composition and undescribed taxa

FB Tamburini, D Maghini, OH Oduaran… - Nature …, 2022 - nature.com
Human gut microbiome research focuses on populations living in high-income countries and
to a lesser extent, non-urban agriculturalist and hunter-gatherer societies. The scarcity of …

Role of carbon monoxide in host–gut microbiome communication

CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

[HTML][HTML] Streptomyces genus as a source of probiotics and its potential for its use in health

S Cuozzo, AM de LeBlanc, JG LeBlanc… - Microbiological …, 2023 - Elsevier
The effect of a probiotic on gut microbiota depends not only on the species of microorganism
but specifically on the strain. In human beings, as in other animals, specific probiotics have …

Activating natural product synthesis using CRISPR interference and activation systems in Streptomyces

A Ameruoso, MC Villegas Kcam, KP Cohen… - Nucleic Acids …, 2022 - academic.oup.com
The rise of antibiotic-resistant bacteria represents a major threat to global health, creating an
urgent need to discover new antibiotics. Natural products derived from the genus …

Treatment with the flavonoid 7, 8-Dihydroxyflavone: A promising strategy for a constellation of body and brain disorders

M Emili, S Guidi, B Uguagliati, A Giacomini… - Critical Reviews in …, 2022 - Taylor & Francis
Flavonoids have long been known to exert benefits in various health problems. Among
them, the BDNF mimetic 7, 8-Dihydroxyflavone (7, 8-DHF) is emerging as a potential …

Vertical stratification in urban green space aerobiomes

JM Robinson, C Cando-Dumancela… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Exposure to a diverse environmental microbiome is thought to play an
important role in “educating” the immune system and facilitating competitive exclusion of …

[HTML][HTML] Obesity and COVID‐19: The mTOR pathway as a possible culprit

A Bolourian, Z Mojtahedi - Obesity Reviews, 2020 - ncbi.nlm.nih.gov
The coronavirus disease 2019 (COVID-19) pandemic, caused by a single-stranded RNA
virus, 1 has demonstrated considerable variations in rate and mortality globally. 2 These …