During the last decade evidence has accumulated that modulation of mRNA stability plays a
central role in cellular homeostasis, including cell differentiation, proliferation and adaptation …

Classical chemotherapeutic agents such as mitotic inhibitors (spindle poisons), alkylating
agents, antimetabolites, topoisomerase inhibitors, and anthracenediones (anthracyclines) …

We sought to determine whether nucleolin, a bcl-2 mRNA-binding protein, has a role in the
regulation of bcl-2 mRNA stability in MCF-7 and MDA-MB-231 breast cancer cells …

B-cell chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal B
cells that are resistant to apoptosis as a result of bcl2 oncogene overexpression. Studies …

bcl-2 mRNA contains an AU-rich element (ARE) that functions in regulating bcl-2 stability.
Our earlier studies indicated that taxol-or okadaic acid-induced bcl-2 mRNA destabilization …

The antiapoptotic Bcl-2 protein is overexpressed in a variety of cancers, particularly
leukemias. In some cell types this is the result of enhanced stability of bcl-2 mRNA, which is …

Pancreatic cancer is a lethal disease owing to its intrinsic and acquired resistance to
therapeutic modalities. The altered balance between pro-and antiapoptosis signals within …

Overexpression of the proto-oncogene bcl-2 promotes abnormal cell survival by inhibiting
apoptosis. Expression of bcl-2 is determined, in part, by regulatory mechanisms that control …

Background and Purpose Adiponectin potently suppresses inflammatory mediator
production. Autophagy is known to play a critical role in the modulation of inflammatory …

The 3′-UTR (untranslated region) of bcl-2 mRNA contains an ARE (AU-rich element) that
potentially regulates the stability of bcl-2 mRNA in a cell specific fashion. Previous studies …