Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …

Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

Cancer-associated fibroblasts (CAFs) are central players in the microenvironment of solid
tumors, affecting cancer progression and metastasis. CAFs have diverse phenotypes …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Myofibroblasts are the construction workers of wound healing and repair damaged tissues
by producing and organizing collagen/extracellular matrix (ECM) into scar tissue. Scar tissue …

Regeneration is the holy grail of tissue repair, but skin injury typically yields fibrotic, non-
functional scars. Develo** pro-regenerative therapies requires rigorous understanding of …

Diabetes is a systemic disease in which patients with diabetes may develop peripheral
neuropathy of the lower extremities and peripheral vascular disease due to long-term …

A wealth of specialized cell populations within the skin facilitates its hair-producing,
protective, sensory, and thermoregulatory functions. How the vast cell-type diversity and …

Injuries to our skin trigger a cascade of spatially-and temporally-synchronized healing
processes. During such endogenous wound repair, the role of fibroblasts is multifaceted …

Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair.
However, both too little and too much vitamin A has deleterious effects. Retinoic acid and …