Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and …

Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

The role of redox molecules, such as NO and ROS, as key mediators of immunity has
recently garnered renewed interest and appreciation. To regulate immune responses, these …

Aneuploidy, a genomic alternation characterized by deviations in the copy number of
chromosomes, affects organisms from early development through to aging. Although it is a …

▪ Abstract Tissue concentrations of both homocysteine (Hcy) and cysteine (Cys) are
maintained at low levels by regulated production and efficient removal of these thiols. The …

Improvements in medical interventions for people with Down's syndrome have led to a
substantial increase in their longevity. Diagnosis and treatment of neurological …

Background Autism is a complex neurodevelopmental disorder that usually presents in early
childhood and that is thought to be influenced by genetic and environmental factors …

Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of
homocysteine–a cytotoxic sulfur-containing amino acid that can induce DNA strand …

Autism is a behaviorally defined neurodevelopmental disorder usually diagnosed in early
childhood that is characterized by impairment in reciprocal communication and speech …