Protein homo-oligomerization is a very common phenomenon, and approximately half of
proteins form homo-oligomeric assemblies composed of identical subunits. The vast majority …

Background Determining a protein's quaternary state, ie the number of monomers in a
functional unit, is a critical step in protein characterization. Many proteins form multimers for …

The identification of physiologically relevant quaternary structures (QSs) in crystal lattices is
challenging. To predict the physiological relevance of a particular QS, QSalign searches for …

Trop2 is a cell-surface transmembrane glycoprotein involved in the maintenance of
epithelial tissue integrity and is an important carcinoma marker. It shares similar claudin …

Motivation While the release of AlphaFold (AF) represented a breakthrough for the
prediction of protein complex structures, its sensitivity, especially when using full length …

Object retrieval systems measure the degree of similarity of the shape of 3D models. They
search for the elements of the 3D model databases that resemble the query model. In …

Proteins often act through oligomeric interactions with other proteins. X-ray crystallography
and cryo-electron microscopy provide detailed information on the structures of biological …

An accurate understanding of biomolecular mechanisms and diseases requires information
on protein quaternary structure (QS). A critical challenge in inferring QS information from …

Understanding protein-protein interactions (PPIs) at the molecular level may lead to
innovations in medicine and biochemistry. The assumption that there are certain “hot spots” …

Botulinum neurotoxins (BoNT) cause the potentially fatal neuroparalytic disease botulism
that arises due to proteolysis of a SNARE protein. Each BoNT is comprised of three …