Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous
system. The microglial production of immune factors is believed to play an important role in …

Abstract Acetyl-L-carnitine (ALC) is an endogenous molecule that not only plays a role in
energy metabolism, but also has antioxidant properties, protects from oxidative stress …

The radical response of peripheral nerves to injury (Wallerian degeneration) is the
cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in …

The AP-1 transcription factor c-Jun is a master regulator of the axonal response in neurons.
c-Jun also functions as a negative regulator of myelination in Schwann cells (SCs) and is …

A rat population with variable responses to nerve injury indicated that activation of
descending inhibition with a spinal noradrenergic component prevents development of …

Back pain is the second leading cause of disability among American adults and is currently
treated either with conservative therapy or interventional pain procedures. However, the …

Understanding the endogenous repair capacity of spinal cord is pivotal to develop strategies
to improve it. Here we design a paradigm of spinal cord lesion in the dorsal column using a …

Spinal cord injury (SCI) impaired sensory fiber transmission leads to chronic, debilitating
neuropathic pain. Sensory afferents are responsive to neurotrophic factors, molecules that …

Neuropathic pain remains one of the most challenging of all neurological diseases and
presents a large unmet need for improved therapies. Many mechanistic details are still …

After CNS injury, axon regeneration is blocked by an inhibitory environment consisting of the
highly upregulated tenascin-C and chondroitin sulfate proteoglycans (CSPGs). Tenascin-C …