Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases
Nucleoside analogues have been in clinical use for almost 50 years and have become
cornerstones of treatment for patients with cancer or viral infections. The approval of several …
cornerstones of treatment for patients with cancer or viral infections. The approval of several …
Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
Epigenetics in cancer: fundamentals and beyond
S Biswas, CM Rao - Pharmacology & Therapeutics, 2017 - Elsevier
Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …
established as the fundamental mechanism leading towards carcinogenesis. Although this …
Synthesis of chiral cyclopentenones
SP Simeonov, JPM Nunes, K Guerra… - Chemical …, 2016 - ACS Publications
The cyclopentenone unit is a very powerful synthon for the synthesis of a variety of bioactive
target molecules. This is due to the broad diversity of chemical modifications available for …
target molecules. This is due to the broad diversity of chemical modifications available for …
Recent advances in the chemical synthesis and evaluation of anticancer nucleoside analogues
Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the
treatment of a wide variety of cancers. Several such compounds, including gemcitabine and …
treatment of a wide variety of cancers. Several such compounds, including gemcitabine and …
Recent progress in DNA methyltransferase inhibitors as anticancer agents
Z Zhang, G Wang, Y Li, D Lei, J **ang… - Frontiers in …, 2022 - frontiersin.org
DNA methylation mediated by DNA methyltransferase is an important epigenetic process
that regulates gene expression in mammals, which plays a key role in silencing certain …
that regulates gene expression in mammals, which plays a key role in silencing certain …
Fluorinated nucleosides: synthesis, modulation in conformation and therapeutic application
Over the last twenty years, fluorination on nucleoside has established itself as the most
promising tool to use to get biologically active compounds that could sustain the clinical trial …
promising tool to use to get biologically active compounds that could sustain the clinical trial …
Synthesis of monofluoroalkenes: a leap forward
M Drouin, JD Hamel, JF Paquin - Synthesis, 2018 - thieme-connect.com
Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry,
and materials science. This review summarizes the most recent advances made regarding …
and materials science. This review summarizes the most recent advances made regarding …
[HTML][HTML] Nucleosidic DNA demethylating epigenetic drugs–a comprehensive review from discovery to clinic
DNA methylation plays a pivotal role in the etiology of cancer by mediating epigenetic
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …
silencing of cancer-related genes. Since the relationship between aberrant DNA methylation …
Palladium-catalyzed C–H allylation of electron-deficient polyfluoroarenes with gem-difluorinated cyclopropanes
PX Zhou, X Yang, J Wang, C Ge, W Feng… - Organic …, 2021 - ACS Publications
A palladium-catalyzed C–H allylation of electron-deficient polyfluoroarenes with gem-
difluorinated cyclopropanes is reported. It provides a useful and facile approach to 2 …
difluorinated cyclopropanes is reported. It provides a useful and facile approach to 2 …