Origins and immunopathogenesis of autoimmune central nervous system disorders

S Ramanathan, F Brilot, SR Irani, RC Dale - Nature Reviews Neurology, 2023 - nature.com
The field of autoimmune neurology is rapidly evolving, and recent discoveries have
advanced our understanding of disease aetiologies. In this article, we review the key …

[HTML][HTML] Stiff-person syndrome and GAD antibody-spectrum disorders: GABAergic neuronal excitability, immunopathogenesis and update on antibody therapies

MC Dalakas - Neurotherapeutics, 2022 - Elsevier
Abstract Although antibodies against Glutamic Acid Decarboxylase (GAD) were originally
associated with Stiff Person Syndrome (SPS), they now denote the “GAD antibody-spectrum …

Autoimmune encephalitis misdiagnosis in adults

EP Flanagan, MD Geschwind… - JAMA …, 2023 - jamanetwork.com
Importance Autoimmune encephalitis misdiagnosis can lead to harm. Objective To
determine the diseases misdiagnosed as autoimmune encephalitis and potential reasons …

[HTML][HTML] Stiff person syndrome spectrum disorders; more than meets the eye

SD Newsome, T Johnson - Journal of neuroimmunology, 2022 - Elsevier
Stiff person syndrome spectrum disorders (SPSD) are a group of rare neuroimmunological
disorders that often include painful spasms and rigidity. However, patients have highly …

GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions

P Tsiortou, H Alexopoulos… - Therapeutic advances in …, 2021 - journals.sagepub.com
Antibodies against glutamic acid decarboxylase (GAD), originally linked to stiff person
syndrome (SPS), now denote the “GAD antibody-spectrum disorders”(GAD-SD) that also …

Temporal lobe epilepsy with GAD antibodies: neurons killed by T cells not by complement membrane attack complex

AR Tröscher, KM Mair, L Verdú de Juan, U Köck… - Brain, 2023 - academic.oup.com
Temporal lobe epilepsy (TLE) is one of the syndromes linked to antibodies against glutamic
acid decarboxylase (GAD). It has been questioned whether 'limbic encephalitis with GAD …

Antibody-mediated autoimmune diseases of the CNS: challenges and approaches to diagnosis and management

E Sechi, EP Flanagan - Frontiers in neurology, 2021 - frontiersin.org
Antibody-mediated disorders of the central nervous system (CNS) are increasingly
recognized as neurologic disorders that can be severe and even life-threatening but with the …

Stiff person spectrum disorder diagnosis, misdiagnosis, and suggested diagnostic criteria

NH Chia, A McKeon, MC Dalakas… - Annals of Clinical …, 2023 - Wiley Online Library
Background Stiff person spectrum disorder (SPSD) is heterogeneous, and accurate
diagnosis can be challenging. Methods Patients referred for diagnosis/suspicion of SPSD at …

Paraneoplastic neurological syndromes of the central nervous system: pathophysiology, diagnosis, and treatment

L Marsili, S Marcucci, J LaPorta, M Chirra, AJ Espay… - Biomedicines, 2023 - mdpi.com
Paraneoplastic neurological syndromes (PNS) include any symptomatic and non-metastatic
neurological manifestations associated with a neoplasm. PNS associated with antibodies …

[HTML][HTML] Immunity, ion channels and epilepsy

TS Chen, MC Lai, HYI Huang, SN Wu… - International journal of …, 2022 - mdpi.com
Epilepsy is a common chronic neurological disorder in modern society. One of the major
unmet challenges is that current antiseizure medications are basically not disease …