Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …

The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

Highlights•NK cell education is endowed by independently-segregating polygenic KIR and
HLA which, combined, enable diverse effector functions.•Education counterbalances each …

Purpose Disease relapse remains a major challenge to successful outcomes in patients who
undergo allogeneic hematopoietic cell transplantation (HCT). Donor natural killer (NK) cell …

NK cells recognize self-HLA via killer Ig-like receptors (KIR). Homeostatic HLA expression
signals for inhibition via KIR, and downregulation of HLA, a common consequence of viral …

Purpose In patients with neuroblastoma (NB), treatment with anti-GD2 monoclonal antibody
(mAb) directs natural killer (NK) cell–mediated antibody-dependent cellular cytotoxicity …

The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity,
influencing predisposition to immune mediated disease, and affecting hematopoietic stem …

Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK)
cells and are key regulators of innate immune responses. NK cells are the first responders in …

Relapse of acute myelogenous leukemia (AML) after allogeneic hematopoietic cell
transplantation (allo HCT) is a major cause of death in transplant recipients. Efforts to control …

Cumulative activating and inhibitory receptor signaling controls the functional output of
individual natural killer (NK) cells. Investigation of how competing signals impact response …