Development and functional diversification of cortical interneurons

L Lim, D Mi, A Llorca, O Marín - Neuron, 2018 - cell.com
In the cerebral cortex, GABAergic interneurons have evolved as a highly heterogeneous
collection of cell types that are characterized by their unique spatial and temporal …

Hippocampal GABAergic inhibitory interneurons

KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

A multimodal cell census and atlas of the mammalian primary motor cortex

Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

[HTML][HTML] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells

NW Gouwens, SA Sorensen, F Baftizadeh, A Budzillo… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

Conserved cell types with divergent features in human versus mouse cortex

RD Hodge, TE Bakken, JA Miller, KA Smith, ER Barkan… - Nature, 2019 - nature.com
Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …

Innovations present in the primate interneuron repertoire

FM Krienen, M Goldman, Q Zhang, R CH del Rosario… - Nature, 2020 - nature.com
Primates and rodents, which descended from a common ancestor around 90 million years
ago, exhibit profound differences in behaviour and cognitive capacity; the cellular basis for …

Shared and distinct transcriptomic cell types across neocortical areas

B Tasic, Z Yao, LT Graybuck, KA Smith, TN Nguyen… - Nature, 2018 - nature.com
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …

A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality

TL Daigle, L Madisen, TA Hage, MT Valley, U Knoblich… - Cell, 2018 - cell.com
Modern genetic approaches are powerful in providing access to diverse cell types in the
brain and facilitating the study of their function. Here, we report a large set of driver and …

[HTML][HTML] Cortical somatostatin interneuron subtypes form cell-type-specific circuits

SJ Wu, E Sevier, D Dwivedi, GA Saldi, A Hairston, S Yu… - Neuron, 2023 - cell.com
The cardinal classes are a useful simplification of cortical interneuron diversity, but such
broad subgrou**s gloss over the molecular, morphological, and circuit specificity of …

Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

M Kannan, G Vasan, S Haziza, C Huang… - Science, 2022 - science.org
Genetically encoded fluorescent voltage indicators are ideally suited to reveal the
millisecond-scale interactions among and between targeted cell populations. However …