Mutational signatures: emerging concepts, caveats and clinical applications
Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Aristolochic acid-associated cancers: a public health risk in need of global action
S Das, S Thakur, M Korenjak, VS Sidorenko… - Nature Reviews …, 2022 - nature.com
Aristolochic acids (AAs) are a group of naturally occurring compounds present in many plant
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …
species of the Aristolochiaceae family. Exposure to AA is a significant risk factor for severe …
Signatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy
Immune checkpoint blockade (ICB) has improved outcomes for patients with advanced
cancer, but the determinants of response remain poorly understood. Here we report …
cancer, but the determinants of response remain poorly understood. Here we report …
The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells
The chemotherapeutic agent CX-5461, or pidnarulex, has been fast-tracked by the United
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …
States Food and Drug Administration for early-stage clinical studies of BRCA1-, BRCA2-and …
Therapeutic and prognostic insights from the analysis of cancer mutational signatures
The somatic mutations in each cancer genome are caused by multiple mutational
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …
The mutational signatures of formalin fixation on the human genome
Clinical archives of patient material near-exclusively consist of formalin-fixed and paraffin-
embedded (FFPE) blocks. The ability to precisely characterise mutational signatures from …
embedded (FFPE) blocks. The ability to precisely characterise mutational signatures from …
[HTML][HTML] APOBEC-mediated mutagenesis is a favorable predictor of prognosis and immunotherapy for bladder cancer patients: evidence from pan-cancer analysis and …
Background: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-
like) family-mediated mutagenesis is widespread in human cancers. However, our …
like) family-mediated mutagenesis is widespread in human cancers. However, our …
Comprehensive investigation of the mutagenic potential of six pesticides classified by IARC as probably carcinogenic to humans
R Martinek, R Lózsa, Á Póti, E Németh, G Várady… - Chemosphere, 2024 - Elsevier
Pesticides are significant environmental pollutants, and many of them possess mutagenic
potential, which is closely linked to carcinogenesis. Here we tested the mutagenicity of all six …
potential, which is closely linked to carcinogenesis. Here we tested the mutagenicity of all six …
The cytidine deaminase APOBEC3G contributes to cancer mutagenesis and clonal evolution in bladder cancer
Mutagenic processes leave distinct signatures in cancer genomes. The mutational
signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers …
signatures attributed to APOBEC3 cytidine deaminases are pervasive in human cancers …