Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections
with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in …

Of the many polypeptide growth factors, transforming growth factor beta (TGF-13) appears to
be relatively unique in its global effects on cell growth and differentiation (1). In addition to its …

Transforming growth factor β1 (TGFβ1) is shown here to be required for yolk sac
haematopoiesis and endothelial differentiation. Mice with a targeted mutation in the TGFβ1 …

Hematopoiesis is a remarkable cell-renewal process that leads to the continuous generation
of large numbers of multiple mature cell types, starting from a relatively small stem cell …

The hematopoietic system is derived from ventral mesoderm. A number of genes that are
important in mesoderm development have been identified including members of the …

The findings reviewed above leave no doubt as to the complexity of actions of TGF-beta, IL-
4, and IL-10 on monocytes/macrophages. Along with MDF, whose actions were recently …

An understanding of mechanisms regulating hematopoietic stem cell engraftment is of
pivotal importance to the clinical use of cultured and genetically modified transplants …

The TGF-β family of ligands, including TGF-β, bone morphogenetic protein (BMP) and
activin, signal through Smad pathways to regulate the fate of hematopoietic progenitor and …

OBJECTIVE: Erythropoiesis is positively regulated by stem cell factor, interleukin 3, and
erythropoietin, which synergize to allow the production of hemoglobinized red blood cells …

Inhibins and activins were initially recognized as gonadal protein hormones which modulate
follicle-stimulating hormone (FSH) production by the anterior pituitary gland. Since the …