The role of helper T cells in psoriasis

P Hu, M Wang, H Gao, A Zheng, J Li, D Mu… - Frontiers in …, 2021 - frontiersin.org
Psoriasis is a complex, chronic relapsing and inflammatory skin disorder with a prevalence
of approximately 2% in the general population worldwide. Psoriasis can be triggered by …

Immunology of psoriasis

MA Lowes, M Suarez-Farinas… - Annual review of …, 2014 - annualreviews.org
The skin is the front line of defense against insult and injury and contains many epidermal
and immune elements that comprise the skin-associated lymphoid tissue (SALT). The …

Scanning the immunopathogenesis of psoriasis

A Chiricozzi, P Romanelli, E Volpe… - International journal of …, 2018 - mdpi.com
Psoriasis is a chronic inflammatory skin disease, the immunologic model of which has been
profoundly revised following recent advances in the understanding of its pathophysiology. In …

The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

R Lande, E Botti, C Jandus, D Dojcinovic… - Nature …, 2014 - nature.com
Psoriasis is a common T-cell-mediated skin disease with 2–3% prevalence worldwide.
Psoriasis is considered to be an autoimmune disease, but the precise nature of the …

Melanocyte antigen triggers autoimmunity in human psoriasis

A Arakawa, K Siewert, J Stöhr, P Besgen… - Journal of Experimental …, 2015 - rupress.org
Psoriasis vulgaris is a common T cell–mediated inflammatory skin disease with a suspected
autoimmune pathogenesis. The human leukocyte antigen (HLA) class I allele, HLA-C* 06 …

Adaptive and innate immunity in psoriasis and other inflammatory disorders

MP Schön - Frontiers in immunology, 2019 - frontiersin.org
Over the past three decades, a considerable body of evidence has highlighted T cells as
pivotal culprits in the pathogenesis of psoriasis. This includes the association of psoriasis …

Current knowledge on psoriasis and autoimmune diseases

N Ayala-Fontánez, DC Soler… - Psoriasis: Targets and …, 2016 - Taylor & Francis
Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk
between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen …

[HTML][HTML] Psoriasis: a STAT3-centric view

E Calautti, L Avalle, V Poli - International journal of molecular sciences, 2018 - mdpi.com
Signal Transducer and Activator of Transcription (STAT) 3 has recently emerged as a key
player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory …

[HTML][HTML] From empirical to pathogenesis-based treatments for psoriasis

PCM van de Kerkhof - Journal of Investigative Dermatology, 2022 - Elsevier
Since the foundation of the European Society for Dermatological Research, pathogenesis of
psoriasis has been studied by many research groups, focusing on various compartments of …

New insights of T cells in the pathogenesis of psoriasis

Y Cai, C Fleming, J Yan - Cellular & molecular immunology, 2012 - nature.com
Psoriasis is one of the most common immune-mediated chronic, inflammatory skin diseases
characterized by hyperproliferative keratinocytes and infiltration of T cells, dendritic cells …