Molecular diagnostics has generated substantial dividends in dissecting the genetic basis of
myeloid neoplasms with eosinophilia. The family of diseases generated by dysregulated …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane …

Background Polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are
clonal myeloproliferative disorders arising from a multipotent progenitor. The loss of …

Polycythemia vera (PV), essential thrombocythemia (ET), and myeloid metaplasia with
myelofibrosis (MMM) are clonal disorders arising from hematopoietic progenitors. An …

Since its discovery two decades ago, the activation of the Janus kinase/signal transducers
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …

Since their discovery as key mediators of cytokine signaling, considerable progress has
been made in defining the structure-function relationships of Signal Transducers and …

Background The V617F mutation, which causes the substitution of phenylalanine for valine
at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with …

Summary The Bcr-Abl tyrosine kinase oncogene causes chronic myelogenous leukemia
(CML) and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) …

Background Idiopathic hypereosinophilic syndrome involves a prolonged state of
eosinophilia associated with organ dysfunction. It is of unknown cause. Recent reports of …

The reduction of iron is an essential step in the transferrin (Tf) cycle, which is the dominant
pathway for iron uptake by red blood cell precursors. A deficiency in iron acquisition by red …