Artificial intelligence-driven drug development against autoimmune diseases
P Moingeon - Trends in pharmacological sciences, 2023 - cell.com
Artificial intelligence (AI)-based predictive models are being used to foster a precision
medicine approach to treat complex chronic diseases such as autoimmune and …
medicine approach to treat complex chronic diseases such as autoimmune and …
Exploring the role of microbial proteins in controlling environmental pollutants based on molecular simulation
J Wu, J Lv, L Zhao, R Zhao, T Gao, Q Xu, D Liu… - Science of the Total …, 2023 - Elsevier
Molecular simulation has been widely used to study microbial proteins' structural
composition and dynamic properties, such as volatility, flexibility, and stability at the …
composition and dynamic properties, such as volatility, flexibility, and stability at the …
HIt Discovery using docking ENriched by GEnerative Modeling (HIDDEN GEM): A novel computational workflow for accelerated virtual screening of ultra‐large …
Recent rapid expansion of make‐on‐demand, purchasable, chemical libraries comprising
dozens of billions or even trillions of molecules has challenged the efficient application of …
dozens of billions or even trillions of molecules has challenged the efficient application of …
[HTML][HTML] Context transcription factors establish cooperative environments and mediate enhancer communication
JF Kribelbauer-Swietek, O Pushkarev… - Nature …, 2024 - pmc.ncbi.nlm.nih.gov
Many enhancers control gene expression by assembling regulatory factor clusters, also
referred to as condensates. This process is vital for facilitating enhancer communication and …
referred to as condensates. This process is vital for facilitating enhancer communication and …
High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display
Tyrosine kinases and SH2 (phosphotyrosine recognition) domains have binding specificities
that depend on the amino acid sequence surrounding the target (phospho) tyrosine residue …
that depend on the amino acid sequence surrounding the target (phospho) tyrosine residue …