The RaPID platform for the discovery of pseudo-natural macrocyclic peptides
Y Goto, H Suga - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Although macrocyclic peptides bearing exotic building blocks have proven their
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …
utility as pharmaceuticals, the sources of macrocyclic peptide drugs have been largely …
Hierarchical materials from high information content macromolecular building blocks: construction, dynamic interventions, and prediction
Hierarchical materials that exhibit order over multiple length scales are ubiquitous in nature.
Because hierarchy gives rise to unique properties and functions, many have sought …
Because hierarchy gives rise to unique properties and functions, many have sought …
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
Abstract γ-Amino acids can play important roles in the biological activities of natural
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo
The absence of orthogonal aminoacyl-transfer RNA (tRNA) synthetases that accept non-l-α-
amino acids is a primary bottleneck hindering the in vivo translation of sequence-defined …
amino acids is a primary bottleneck hindering the in vivo translation of sequence-defined …
Selection of Nucleotide-Encoded Mass Libraries of Macrocyclic Peptides for Inaccessible Drug Targets
K Colas, D Bindl, H Suga - Chemical Reviews, 2024 - ACS Publications
Technological advances and breakthrough developments in the pharmaceutical field are
knocking at the door of the “undruggable” fortress with increasing insistence. Notably, the …
knocking at the door of the “undruggable” fortress with increasing insistence. Notably, the …
In vitro genetic code reprogramming for the expansion of usable noncanonical amino acids
T Katoh, H Suga - Annual Review of Biochemistry, 2022 - annualreviews.org
Genetic code reprogramming has enabled us to ribosomally incorporate various
nonproteinogenic amino acids (npAAs) into peptides in vitro. The repertoire of usable npAAs …
nonproteinogenic amino acids (npAAs) into peptides in vitro. The repertoire of usable npAAs …
Directing evolution of novel ligands by mRNA display
mRNA display is a powerful biological display platform for the directed evolution of proteins
and peptides. mRNA display libraries covalently link the displayed peptide or protein …
and peptides. mRNA display libraries covalently link the displayed peptide or protein …
A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation
Adenosine triphosphate-binding cassette (ABC) transporters, such as multidrug resistance
protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across …
protein 1 (MRP1), protect against cellular toxicity by exporting xenobiotic compounds across …
Cell-free gene expression: methods and applications
Cell-free gene expression (CFE) systems empower synthetic biologists to build biological
molecules and processes outside of living intact cells. The foundational principle is that …
molecules and processes outside of living intact cells. The foundational principle is that …
Atomistic simulations of the Escherichia coli ribosome provide selection criteria for translationally active substrates
As genetic code expansion advances beyond l-α-amino acids to backbone modifications
and new polymerization chemistries, delineating what substrates the ribosome can …
and new polymerization chemistries, delineating what substrates the ribosome can …