Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies
Cancer cells establish replicative immortality by activating a telomere-maintenance
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …
mechanism (TMM), be it telomerase or the alternative lengthening of telomeres (ALT) …
Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks
To escape replicative senescence, cancer cells have to overcome telomere attrition during
DNA replication. Most of cancers rely on telomerase to extend and maintain telomeres, but 4 …
DNA replication. Most of cancers rely on telomerase to extend and maintain telomeres, but 4 …
TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R-to D-loop switch
Alternative lengthening of telomeres (ALT), a telomerase-independent process maintaining
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
telomeres, is mediated by break-induced replication (BIR). RAD52 promotes ALT by …
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
The response to poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
RAD51AP1 regulates ALT-HDR through chromatin-directed homeostasis of TERRA
N Kaminski, AR Wondisford, Y Kwon, ML Lynskey… - Molecular cell, 2022 - cell.com
Alternative lengthening of telomeres (ALT) is a homology-directed repair (HDR) mechanism
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
of telomere elongation that controls proliferation in subsets of aggressive cancer. Recent …
TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
B Silva, R Arora, S Bione, CM Azzalin - Nature communications, 2021 - nature.com
Abstract Alternative Lengthening of Telomeres (ALT) is a Break-Induced Replication (BIR)-
based mechanism elongating telomeres in a subset of human cancer cells. While the notion …
based mechanism elongating telomeres in a subset of human cancer cells. While the notion …
Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52
Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere
maintenance mechanism that occurs in a subset of cancers. One of the hallmarks of ALT …
maintenance mechanism that occurs in a subset of cancers. One of the hallmarks of ALT …
Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies
Alternative lengthening of telomeres (ALT) is mediated by break-induced replication (BIR),
but how BIR is regulated at telomeres is poorly understood. Here, we show that telomeric …
but how BIR is regulated at telomeres is poorly understood. Here, we show that telomeric …
Nuclear body phase separation drives telomere clustering in ALT cancer cells
Telomerase-free cancer cells employ a recombination-based alternative lengthening of
telomeres (ALT) pathway that depends on ALT-associated promyelocytic leukemia nuclear …
telomeres (ALT) pathway that depends on ALT-associated promyelocytic leukemia nuclear …
Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3
F Richards, MJ Llorca-Cardenosa, J Langton… - Nature …, 2023 - nature.com
Abstract Although Poly (ADP-ribose)-polymerases (PARPs) are key regulators of genome
stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we …
stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we …