Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Background Mechanical ventilation (MV) is a core intensive care unit (ICU) therapy.
Significant inter-and intra-patient variability in lung mechanics and condition makes …

Mechanical ventilation (MV) is a core life-support therapy for patients suffering from
respiratory failure or acute respiratory distress syndrome (ARDS). Respiratory failure is a …

Background Mechanical ventilation is an essential therapy to support critically ill respiratory
failure patients. Current standards of care consist of generalised approaches, such as the …

Mechanical ventilation is a life-support therapy for intensive care patients suffering from
respiratory failure. To reduce the current rate of ventilator-induced lung injury requires …

Setting PEEP to target optimal compliance can overcome these pitfalls. When an increase in
PEEP benefits any patient, functional lung units are recruited and compliance increases. If …

The rise of model-based and machine learning methods have created increasingly realistic
opportunities to implement personalized, patient-specific mechanical ventilation (MV) in the …

Background Patient-specific lung mechanics during mechanical ventilation (MV) can be
identified from measured waveforms of fully ventilated, sedated patients. However …

Abstract Background and Objectives Mechanical ventilation (MV) is a primary therapy for
patients with acute respiratory failure. However, poorly selected ventilator settings can cause …