The last 10 years witnessed an acceleration of our understanding of what genetic factors
underpin the risk of breast cancer. Rare high-and moderate-penetrance variants such as …

The susceptibility gene for ataxia telangiectasia, ATM, is also an intermediate-risk breast-
cancer-susceptibility gene. However, the spectrum and frequency distribution of ATM …

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) genes are present in about 50% of
cases of hereditary breast cancer. Proteins encoded by these genes are key players in DNA …

Background MicroRNAs (miRNAs) negatively regulate the gene expression and act as
tumor suppressors or oncogenes in oncogenesis. The association between single …

The ATM gene is mutated in the syndrome, ataxia-telangiectasia (AT), which is
characterized by predisposition to cancer. Patients with AT have an elevated risk of breast …

Ataxia telangiectasia mutated (ATM) is a key gene in DNA double-strand break (DSB), and
therefore, most of its disabling genetic alterations play an important initiative role in many …

PURPOSE Little is known about the genetic predisposition to breast and ovarian cancer
among the Chilean population, in particular genetic predisposition beyond BRCA1 and …

Background The ATM gene has been frequently involved in hereditary breast cancer as a
low-penetrance susceptibility gene but evidence regarding the role of ATM as a breast …

MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or
oncogenes in oncogenesis. The association between a single nucleotide polymorphism …

Background Emerging evidence suggests that ataxia telangiectasia-mutated (ATM) is
involved in numerous damage repair signaling pathways and cell-cycle checkpoints …