Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …

14-3-3 proteins are a family of proteins expressed throughout the body and implicated in
many diseases, from cancer to neurodegenerative disorders. While these proteins do not …

This article is dedicated to the memory of Michael G. Rossmann. Dating back to the last
universal common ancestor, P-loop NTPases and Rossmanns comprise the most ubiquitous …

We consider the differences between the many-pathway protein folding model derived from
theoretical energy landscape considerations and the defined-pathway model derived from …

Mechanisms of emergence and divergence of protein folds pose central questions in
biological sciences. Incremental mutation and stepwise adaptation explain relationships …

Conspectus The design and study of miniproteins, that is, polypeptide chains< 40 amino
acids in length that adopt defined and stable 3D structures, is resurgent. Miniproteins offer …

Protein-protein interactions (PPIs) mediate a variety of cellular processes and form complex
networks, where connectivity is achieved owing to the “hub” proteins whose interaction with …

Natural evolution has generated an impressively diverse protein universe via duplication
and recombination from a set of protein fragments that served as building blocks. The …

The design of tailor-made enzymes is a major goal in biochemical research that can result in
wide-range applications and will lead to a better understanding of how proteins fold and …

RNA-binding proteins (RBPs) play a pivotal role in the lifespan of RNAs. The disfunction of
RBPs is frequently the cause of cell disorders which are incompatible with life. Furthermore …