Acquired drug resistance represents a major clinical problem and one of the biggest
limitations of chemotherapeutic regimens in colorectal cancer. Combination regimens using …

Objective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide.
Defining critical research gaps (RG), their prioritisation and resolution, could improve patient …

Background The number of clinical studies evaluating the benefit of cytokine-induced killer
cell (CIK) therapy, an adoptive immunotherapy, for colorectal cancer (CRC) is increasing. In …

Inherent and acquired chemoresistance reduce the effectiveness of irinotecan in the
treatment of metastatic colorectal cancer (CRC). However, the molecular mechanisms …

Abstract Purpose of Review Treatment options for patients with metastatic colorectal cancer
continue to advance as the therapeutic implications of the molecular subtypes of this …

Current decision‐guiding algorithms in cancer drug treatment are based on decades of
research and numerous clinical trials. For the majority of patients, this data is successfully …

Radiotherapy (RT) can be used as preoperative treatment to downstage initially
unresectable locally rectal carcinoma, but radioresistance and recurrence remain significant …

Background Colorectal cancer is the third most prevalent cancer in the world, preceded by
prostate and lung cancers in men (10%) and breast and lung cancers in women (9.4%) …

Background The surgical and oncological outcome of extra-levator abdominoperineal
excision (ELAPE) procedure remains unclear in low rectal cancer. Methods A total of 194 …

The term “malignant polyp” refers to any polyp of the colon or rectum harboring malignancy
that invades through the muscularis mucosa. Management of these polyps has …