Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

DE Tylawsky, H Kiguchi, J Vaynshteyn, J Gerwin… - Nature materials, 2023 - nature.com
Medulloblastoma is the most common malignant paediatric brain tumour, with~ 30%
mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic …

The entry of nanoparticles into solid tumours

S Sindhwani, AM Syed, J Ngai, BR Kingston… - Nature materials, 2020 - nature.com
The concept of nanoparticle transport through gaps between endothelial cells (inter-
endothelial gaps) in the tumour blood vessel is a central paradigm in cancer nanomedicine …

Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

J Li, K Kataoka - Journal of the American Chemical Society, 2020 - ACS Publications
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …

Magnetic nanoparticles in targeted drug delivery: a review

E Kianfar - Journal of Superconductivity and Novel Magnetism, 2021 - Springer
Magnetic nanoparticles are one of the most important and widely used types of
nanomaterials, whose unique properties make them special compared to other …

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

N Boehnke, JP Straehla, HC Safford, M Kocak… - Science, 2022 - science.org
To accelerate the translation of cancer nanomedicine, we used an integrated genomic
approach to improve our understanding of the cellular processes that govern nanoparticle …

Effect of the surface modification, size, and shape on cellular uptake of nanoparticles

S Salatin, S Maleki Dizaj… - Cell biology …, 2015 - Wiley Online Library
Nowadays successful application of nanoparticles for therapeutic objects needs the effective
uptake of them by cells. Hence, studying of the interaction of nanoparticles with cell …

Surface-engineered dendrimers in gene delivery

J Yang, Q Zhang, H Chang, Y Cheng - Chemical reviews, 2015 - ACS Publications
1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

The use of human umbilical vein endothelial cells (HUVECs) as an in vitro model to assess the toxicity of nanoparticles to endothelium: a review

Y Cao, Y Gong, L Liu, Y Zhou, X Fang… - Journal of Applied …, 2017 - Wiley Online Library
With the rapid development of nanotechnologies, nanoparticles (NPs) are increasingly
produced and used in many commercial products, which could lead to the contact of human …