Alzheimer's disease is the most common form of dementia and its pathological hallmarks
include the loss of neurones through cell death, as well as the accumulation of amyloid …

In the last few years several experimental strategies based on epi-, confocal and two photon
excitation fluorescence microscopy techniques have been employed to study the lateral …

Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

It is thought that magainin 2, an antimicrobial peptide, acts by binding to lipid membranes.
Recent studies using a suspension of large unilamellar vesicles (LUVs) indicate that …

The aggregation of soluble proteins into fibrillar species is a complex process that spans
many lengths and time scales, and that involves the formation of numerous on-pathway and …

It is well established that Alzheimer's amyloid β-peptides reduce the membrane barrier to ion
transport. The prevailing model ascribes the resulting interference with ion homeostasis to …

Membrane lysis caused by antibiotic peptides is often rationalized by means of two different
models: the so-called carpet model and the pore-forming model. We report here on the lytic …

Accumulation of amyloid beta (Aβ) peptide and its aggregates in the human brain is
considered as one of the hallmarks of Alzheimer's disease (AD). The polymorphic oligomers …

The aggregation and deposition onto neuronal cells of amyloid β-peptide (Aβ) is central to
the pathogenesis of Alzheimer's disease. Accumulating evidence suggests that membranes …

The main pathological features in the Alzheimer's brain are progressive depositions of
amyloid protein plaques among nerve cells, and neurofibrillary tangles within the nerve …