Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly
evolving, making it possible to comprehensively characterize cells and tissues in health and …

Unravelling spatio-temporal patterns of gene expression is crucial to understanding core
biological principles from embryogenesis to disease. Here we review emerging …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Classification and characterization of neuronal types are critical for understanding their
function and dysfunction. Neuronal classification schemes typically rely on measurements of …

The human body is constantly exposed to microorganisms, which entails manifold
interactions between human cells and diverse commensal or pathogenic bacteria. The …

Common and rare alleles are now being annotated across millions of human genomes, and
omics technologies are increasingly being used to develop health and treatment …

Spermatogenesis is a complex differentiation process coordinated spatiotemporally across
and along seminiferous tubules. Cellular heterogeneity has made it challenging to obtain …

To achieve a complete understanding of how organisms function, there is a need to study
their fundamental unit, the cell, in its spatial context. In recent years, we have seen fast …

Although our understanding of both bacterial cell physiology and the complex behaviors
exhibited by bacterial biofilms is expanding rapidly, we cannot yet sum the behaviors of …

Interpreting the mechanisms and principles that govern gene activity and how these genes
work according to-their cellular distribution in organisms has profound implications for …