The structures and functions of correlations in neural population codes

S Panzeri, M Moroni, H Safaai… - Nature Reviews …, 2022 - nature.com
The collective activity of a population of neurons, beyond the properties of individual cells, is
crucial for many brain functions. A fundamental question is how activity correlations between …

Volume electron microscopy

CJ Peddie, C Genoud, A Kreshuk, K Meechan… - Nature Reviews …, 2022 - nature.com
Life exists in three dimensions, but until the turn of the century most electron microscopy
methods provided only 2D image data. Recently, electron microscopy techniques capable of …

Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography

CL Walsh, P Tafforeau, WL Wagner, DJ Jafree… - Nature …, 2021 - nature.com
Imaging intact human organs from the organ to the cellular scale in three dimensions is a
goal of biomedical imaging. To meet this challenge, we developed hierarchical phase …

Connectomic comparison of mouse and human cortex

S Loomba, J Straehle, V Gangadharan, N Heike… - Science, 2022 - science.org
The human cerebral cortex houses 1000 times more neurons than that of the cerebral cortex
of a mouse, but the possible differences in synaptic circuits between these species are still …

The extremely brilliant source storage ring of the european synchrotron radiation facility

P Raimondi, C Benabderrahmane, P Berkvens… - Communications …, 2023 - nature.com
Abstract The Extremely Brilliant Source (EBS) is the experimental implementation of the
novel Hybrid Multi Bend Achromat (HMBA) storage ring magnetic lattice concept, which has …

Anipose: A toolkit for robust markerless 3D pose estimation

P Karashchuk, KL Rupp, ES Dickinson, S Walling-Bell… - Cell reports, 2021 - cell.com
Quantifying movement is critical for understanding animal behavior. Advances in computer
vision now enable markerless tracking from 2D video, but most animals move in 3D. Here …

Connectomic reconstruction of a female Drosophila ventral nerve cord

A Azevedo, E Lesser, JS Phelps, B Mark, L Elabbady… - Nature, 2024 - nature.com
A deep understanding of how the brain controls behaviour requires map** neural circuits
down to the muscles that they control. Here, we apply automated tools to segment neurons …

[HTML][HTML] Reconstruction of motor control circuits in adult Drosophila using automated transmission electron microscopy

JS Phelps, DGC Hildebrand, BJ Graham, AT Kuan… - Cell, 2021 - cell.com
To investigate circuit mechanisms underlying locomotor behavior, we used serial-section
electron microscopy (EM) to acquire a synapse-resolution dataset containing the ventral …

A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution

A Shapson-Coe, M Januszewski, DR Berger, A Pope… - Science, 2024 - science.org
To fully understand how the human brain works, knowledge of its structure at high resolution
is needed. Presented here is a computationally intensive reconstruction of the ultrastructure …

[HTML][HTML] Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch

A Handler, Q Zhang, S Pang, TM Nguyen, M Iskols… - Neuron, 2023 - cell.com
Across mammalian skin, structurally complex and diverse mechanosensory end organs
respond to mechanical stimuli and enable our perception of dynamic, light touch. How forces …