Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

This narrative review is concerned with genetic variants of the genes encoding
gonadotrophin subunits and their receptors, as well as their implications into the diagnosis …

G protein-coupled receptors (GPCRs) are plasma membrane proteins associated with an
array of functions. Mutations in these receptors lead to a number of genetic diseases …

Signal transduction by luteinizing hormone receptors (LHRs) and follicle-stimulating
hormone receptors (FSHRs) is essential for the successful reproduction of human beings …

G protein‐coupled receptors (GPCRs) are central to the functioning of the hypothalamic–
pituitary–gonadal axis (HPG axis) and include the rhodopsin‐like GPCR family members …

Mutations in G protein-coupled receptors (GPCRs) underlie numerous diseases. Many
cause receptor misfolding and failure to reach the cell surface. Pharmacological chaperones …

Misfolding of G protein-coupled receptors (GPCRs) caused by mutations frequently leads to
disease due to intracellular trap** of the conformationally abnormal receptor. Several …

G protein-coupled receptors (GPCRs) facilitate the majority of signal transductions across
cell membranes in humans, with numerous diseases attributed to inactivating GPCR …

Proteins are synthesized in the endoplasmic reticulum (ER) of the cell, where a strict quality
control system (QCS) guards against aberrant protein structures and non-productive protein …

Background: Luteinizing hormone (LH) and human chorionic gonadotropin (hCG)
preparations are widely used in medicine to correct reproductive disorders, but are …