The WHO 2021 Classification of Central Nervous System tumours: a practical update on what neurosurgeons need to know—a minireview
Abstract Background The World Health Organization (WHO) Classification of Tumours, also
known as WHO Blue Books, represents an international standardised tool in the diagnostic …
known as WHO Blue Books, represents an international standardised tool in the diagnostic …
Medulloblastoma
Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
Ultra-fast deep-learned CNS tumour classification during surgery
Central nervous system tumours represent one of the most lethal cancer types, particularly
among children. Primary treatment includes neurosurgical resection of the tumour, in which …
among children. Primary treatment includes neurosurgical resection of the tumour, in which …
Intertumoral heterogeneity within medulloblastoma subgroups
While molecular subgrou** has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
Outcomes by clinical and molecular features in children with medulloblastoma treated with risk-adapted therapy: results of an international phase III trial (SJMB03)
PURPOSE SJMB03 (ClinicalTrials. gov identifier: NCT00085202) was a phase III risk-
adapted trial that aimed to determine the frequency and clinical significance of biological …
adapted trial that aimed to determine the frequency and clinical significance of biological …
Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy
Conventional methods for intraoperative histopathologic diagnosis are labour-and time-
intensive, and may delay decision-making during brain-tumour surgery. Stimulated Raman …
intensive, and may delay decision-making during brain-tumour surgery. Stimulated Raman …
Medulloblastoma in the age of molecular subgroups: a review: JNSPG 75th Anniversary Invited Review Article
Medulloblastoma is the most common pediatric malignant brain tumor. Advances in
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …
molecular profiling have uncovered significant heterogeneity among medulloblastomas and …
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological
variables pertaining to age, presence of metastases, extent of resection, histological …
variables pertaining to age, presence of metastases, extent of resection, histological …
MRI radiogenomics of pediatric medulloblastoma: a multicenter study
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB
risk stratification, which may aid therapeutic decision making, family counseling, and …
risk stratification, which may aid therapeutic decision making, family counseling, and …
Medulloblastoma: from myth to molecular
Current therapies for medulloblastoma were introduced primarily in the 1980s and consist of
predominantly cytotoxic, nontargeted approaches. Mortality from medulloblastoma remains …
predominantly cytotoxic, nontargeted approaches. Mortality from medulloblastoma remains …