Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS
proteins integrate signals from a wide array of receptors and initiate downstream signaling …

RAS is a founding member of the RAS superfamily of GTPases. These small 21 kDa proteins
function as molecular switches to initialize signaling cascades involved in various cellular …

The KRAS gene is one of the most frequently mutated oncogenes in human cancer and
gives rise to two isoforms, KRAS4A and KRAS4B. KRAS post-translational modifications …

RASopathies are a group of related genetic disorders caused by mutations in genes within
the RAS/MAPK signaling pathway. This pathway is crucial for cell division, growth, and …

RAS proteins function as highly regulated molecular switches that control cellular growth. In
addition to regulatory proteins, RAS undergoes a number of posttranslational modifications …

Abstract Small GTPase or Ras superfamily, including Ras, Rho, Rab, Ran and Arf, are
fundamental in regulating a wide range of cellular processes such as growth, differentiation …

A cancer outcome is a multifactorial event that comes from both exogenous injuries and an
endogenous predisposing background. The healthy state is guaranteed by the fine-tuning of …

Ras signaling plays an important role in growth, proliferation, and developmental patterning.
Maintaining appropriate levels of Ras signaling is important to establish patterning in …

_ Lysine is the basis of lysine acylation (which formed upon AT-Pase effective function which
regulated by lysine “AAG AAA”) important for aminoacyl-tRNAs production which regulate …

Abstract T cell receptor (TCR)-T cell immunotherapy, in which T cells are engineered to
express a TCR targeting a tumor epitope, is a form of adoptive cell therapy (ACT) that has …