Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

The successful in vivo implementation of gene expression modulation strategies relies on
effective, non-immunogenic delivery vehicles. Lipid nanoparticles are one of the most …

Vedolizumab is a novel therapeutic monoclonal antibody recently approved for the treatment
of moderately to severely active ulcerative colitis and Crohn's disease in adults who have …

Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammation of the
gastrointestinal tract with a highly heterogeneous presentation. It has a relapsing and …

Recognition of laminin by integrin receptors is central to the epithelial cell adhesion to
basement membrane, but the structural background of this molecular interaction remained …

Intestinal immune cell trafficking has been identified as a central event in the pathogenesis
of inflammatory bowel diseases (IBD). Intensive research on different aspects of the immune …

Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus
disease 2019 (COVID-19)-induced infection, is strongly associated with various …

Integrin αvβ8 binds with exquisite specificity to latent transforming growth factor-β (L-TGF-β).
This binding is essential for activating L-TGF-β presented by a variety of cell types. Inhibiting …

Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured eight distinct RGD-
bound conformations of the αIIbβ3 integrin headpiece. Starting from the closed βI domain …