DNA methylation landscapes of prostate cancer brain metastasis are shaped by early driver genetic alterations

J Gallon, A Rodriguez-Calero, A Benjak… - Cancer …, 2023 - aacrjournals.org
Metastases from primary prostate cancers to rare locations, such as the brain, are becoming
more common due to longer life expectancy resulting from improved treatments. Epigenetic …

[HTML][HTML] Association of epigenetic landscapes with heterogeneity and plasticity in pancreatic cancer

P Manoukian, LC Kuhnen, HWM van Laarhoven… - Critical Reviews in …, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Due to a lack of clear
symptoms, patients often present with advanced disease, with limited clinical intervention …

Correlation analysis for alterations of intestinal flora in hepatocellular carcinoma patients: combinatorial detection of Coriobacterium, Atopobium, Coprococcus and …

W Xu, Y Jiang, J Tao, Y Liu, Y **a… - Journal of medical …, 2023 - microbiologyresearch.org
Introduction. Hepatocellular carcinoma (HCC) is one of the most common malignant tumours
in the world. Due to the characteristics of low early diagnosis rate, high malignancy and …

In Vitro Human Liver Model for Toxicity Assessment with Clinical and Preclinical Instrumentation

E Madorran, L Kocbek Šaherl, M Rakuša, M Munda - Pharmaceutics, 2024 - mdpi.com
The existing in vitro toxicological models lack translational potential, which makes difficult
the application of gathered information to clinical usage. To tackle this issue, we built a …

The role of chronic liver diseases in the emergence and recurrence of hepatocellular carcinoma: An omics perspective

S Zanotti, GF Boot, M Coto-Llerena, J Gallon… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) typically develops from a background of cirrhosis resulting
from chronic inflammation. This inflammation is frequently associated with chronic liver …

Uncovering the effects of early life cigarette smoke exposure on offspring lung function and DNA methylation patterns using a mouse model

CD Onuzulu - 2024 - mspace.lib.umanitoba.ca
Early life cigarette smoke (CS) exposure has been associated with the development of sex-
specific, persistent health deficits in offspring, and changes in epigenetic marks such as …

Correlation analysis for the alterations of intestinal flora and their metabolite in hepatocellular carcinoma patients

W Xu, Y Jiang, JL Tao, YH Liu, YW **a, C Chen… - 2022 - researchsquare.com
Hepatocellular Carcinoma (HCC) is one of the most common malignant tumors in the world.
There are a variety of treatment options for HCC, such as hepatectomy, radio frequency …