Quinolones have been discovered in our laboratory as a new class of antifilarial agents. This
has led to the design, synthesis, and antifilarial evaluation of a number of N-substituted …

The main problem regarding the chemotherapy of filariasis is that no safe and effective drug
is available yet to combat the adult human filarial worms. Setaria cervi, the causal organism …

Filariasis, caused by spirunid nematodes, is one of the most prevalent diseases of tropical
and subtropical countries and encompasses a number of different pathological conditions. It …

A series of 21 compounds of trisubstituted pyrimidine derivatives have been synthesized
and evaluated for their in vitro topoisomerase II inhibitory activity against filarial parasite …

Targeting polyamines of parasitic protozoa in chemotherapy has attracted attention because
polyamines might reveal novel drug targets for antiparasite therapies (Müller et al. 2001) …

NMR spectroscopy was used to characterize the binding properties of polyamines to
Escherichia coli tRNA. The 15N NMR spectra of three 15N-enriched N-substituted …

Genomic DNA was isolated from the lichen Evernia prunastri in order to analyze by high-
performance liquid chromatography the occurrence of polyamines conjugated to the …